Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Am J Trop Med Hyg. 2011 Oct;85(4):660-6. doi: 10.4269/ajtmh.2011.11-0058.
This study aims to evaluate the current seroprevalence of toxoplasmosis among indigenous communities in Peninsular Malaysia and relate its association with epidemiological data. Overall seroprevalence of Toxoplasma gondii was 37.0% with 31.0% immunoglobulin (Ig) G, 1.8% IgM, and 4.2% seropositivity for both anti-Toxoplasma antibodies. Multivariate analysis showed that age above 12 years (odds ratio [OR] = 2.70, 95% confidence interval [CI] = 1.75-4.04, P < 0.001), using untreated river and mountain water supplies (OR = 1.50, 95% CI = 1.01-2.40, P = 0.050), and close proximity with cats (OR = 1.40, 95% CI = 1.10-1.76, P = 0.010) were factors associated with toxoplasmosis. Given the high seroprevalence of toxoplasmosis among these communities who live in poor socioeconomic conditions, a comprehensive health surveillance program and screening should be initiated among women of childbearing age and pregnant women during the antenatal period for early diagnosis and treatment. The role of domestic cats and environmental contamination with oocyst in soil and water has to be highlighted and addressed in future prevention strategies for these communities.
本研究旨在评估马来西亚半岛原住民社区中弓形虫病的现患率，并探讨其与流行病学数据的关联。总体而言，Toxoplasma gondii 的血清阳性率为 37.0%，其中 IgG 为 31.0%、IgM 为 1.8%、两种抗弓形虫抗体均为 4.2%。多变量分析显示，年龄大于 12 岁（比值比 [OR] = 2.70，95%置信区间 [CI] = 1.75-4.04，P < 0.001）、使用未经处理的河山水源（OR = 1.50，95% CI = 1.01-2.40，P = 0.050）和与猫近距离接触（OR = 1.40，95% CI = 1.10-1.76，P = 0.010）是与弓形虫病相关的因素。鉴于这些生活在贫困社会经济条件下的社区中弓形虫病的高血清阳性率，应在育龄妇女和产前期间启动全面的健康监测计划和筛查，以便早期诊断和治疗。应强调并解决家猫和土壤与水中卵囊环境污染在未来这些社区的预防策略中的作用。
