用于进一步开发胶质瘤疫苗的EPHA2上T细胞表位的发现：一项免疫组学研究
T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study.
作者信息
Wiwanitkit Viroj
机构信息
Wiwanitkit House, Bangkhae, Bangkok, Thailand.
出版信息
J Pediatr Neurosci. 2011 Jan;6(1):2-3. doi: 10.4103/1817-1745.84398.
Abstract
BACKGROUND
Glioma is a deadly neurological tumor. For modern management of glioma, glioma vaccinotherapy is the new concept.
MATERIALS AND METHODS
Based on present biomedical technique, the identification of T-cell epitopes via MHC mapping can help clarify the inter-relationship of tumor and immune system. This process can be performed using advanced immunoinformatics technique.
RESULTS
Here, the author performs an immunoinformatics analysis to find alternative epitopes for glioma-related antigen, EPHA2.
CONCLUSION
After complete manipulation on EPHA2 molecules, the five best epitopes were derived.
摘要
背景
神经胶质瘤是一种致命的神经肿瘤。对于神经胶质瘤的现代治疗，神经胶质瘤疫苗疗法是一个新概念。
材料与方法
基于当前的生物医学技术，通过MHC图谱鉴定T细胞表位有助于阐明肿瘤与免疫系统之间的相互关系。这一过程可使用先进的免疫信息学技术来完成。
结果
在此，作者进行了一项免疫信息学分析，以寻找神经胶质瘤相关抗原EPHA2的替代表位。
结论
对EPHA2分子进行完整操作后，得出了五个最佳表位。
相似文献
1
T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study.用于进一步开发胶质瘤疫苗的EPHA2上T细胞表位的发现：一项免疫组学研究
J Pediatr Neurosci. 2011 Jan;6(1):2-3. doi: 10.4103/1817-1745.84398.
2
A novel vaccine containing EphA2 epitope and LIGHT plasmid induces robust cellular immunity against glioma U251 cells.一种含有 EphA2 表位和 LIGHT 质粒的新型疫苗可诱导针对神经胶质瘤 U251 细胞的强烈细胞免疫。
Cell Immunol. 2011;272(1):102-6. doi: 10.1016/j.cellimm.2011.08.011. Epub 2011 Aug 31.
3
Finding a T-cell epitope for a melanoma vaccine by an immunomics technique.通过免疫组学技术寻找黑色素瘤疫苗的T细胞表位。
Asian Pac J Cancer Prev. 2006 Oct-Dec;7(4):659-60.
4
A Proteome-Wide Immunoinformatics Tool to Accelerate T-Cell Epitope Discovery and Vaccine Design in the Context of Emerging Infectious Diseases: An Ethnicity-Oriented Approach.一种基于蛋白质组学的免疫信息学工具，用于加速新兴传染病背景下的 T 细胞表位发现和疫苗设计：一种面向种族的方法。
Front Immunol. 2021 Feb 26;12:598778. doi: 10.3389/fimmu.2021.598778. eCollection 2021.
5
6
EphA2 as a glioma-associated antigen: a novel target for glioma vaccines.EphA2作为一种胶质瘤相关抗原：胶质瘤疫苗的新靶点。
Neoplasia. 2005 Aug;7(8):717-22. doi: 10.1593/neo.05277.
7
Immunoinformatics Approach for the Identification and Characterization of T Cell and B Cell Epitopes towards the Peptide-Based Vaccine against SARS-CoV-2.免疫信息学方法鉴定和分析针对 SARS-CoV-2 的基于肽的疫苗的 T 细胞和 B 细胞表位。
Arch Med Res. 2021 May;52(4):362-370. doi: 10.1016/j.arcmed.2021.01.004. Epub 2021 Jan 29.
8
An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice.一种基于免疫信息学的 DNA 疫苗，编码埃博拉病毒、苏丹病毒和委内瑞拉马脑炎病毒的人类 II 类 T 细胞表位，在 HLA 转基因小鼠中具有免疫原性。
Hum Vaccin Immunother. 2017 Dec 2;13(12):2824-2836. doi: 10.1080/21645515.2017.1329788. Epub 2017 Jun 2.
9
Overlapping CD8+ and CD4+ T-cell epitopes identification for the progression of epitope-based peptide vaccine from nucleocapsid and glycoprotein of emerging Rift Valley fever virus using immunoinformatics approach.应用免疫信息学方法鉴定新型裂谷热病毒核衣壳蛋白和糖蛋白中基于表位的肽疫苗进展的 CD8+和 CD4+ T 细胞表位重叠
Infect Genet Evol. 2017 Dec;56:75-91. doi: 10.1016/j.meegid.2017.10.022. Epub 2017 Nov 1.
10
Development a multi-epitope driven subunit vaccine for immune response reinforcement against Serogroup B of Neisseria meningitidis using comprehensive immunoinformatics approaches.采用综合免疫信息学方法，开发针对脑膜炎奈瑟菌 B 群的多表位驱动亚单位疫苗以增强免疫应答。
Infect Genet Evol. 2019 Nov;75:103992. doi: 10.1016/j.meegid.2019.103992. Epub 2019 Aug 5.
本文引用的文献
1
[Glioblastoma treatment in 2010].[2010年的胶质母细胞瘤治疗]
Rev Med Brux. 2009 Sep-Oct;30(5):496-505.
2
Monitoring immune responses after glioma vaccine immunotherapy.监测胶质瘤疫苗免疫治疗后的免疫反应。
Neurosurg Clin N Am. 2010 Jan;21(1):195-9. doi: 10.1016/j.nec.2009.09.004.
3
Clinical applications of a peptide-based vaccine for glioblastoma.一种基于肽的胶质母细胞瘤疫苗的临床应用
Neurosurg Clin N Am. 2010 Jan;21(1):95-109. doi: 10.1016/j.nec.2009.09.001.
4
Heat-shock protein vaccines as active immunotherapy against human gliomas.热休克蛋白疫苗作为针对人类神经胶质瘤的主动免疫治疗。
Expert Rev Anticancer Ther. 2009 Nov;9(11):1577-82. doi: 10.1586/era.09.104.
5
Vaccine therapy with dendritic cells transfected with Il13ra2 mRNA for glioma in mice.用转染 Il13ra2 mRNA 的树突状细胞进行小鼠脑胶质瘤的疫苗治疗。
J Neurosurg. 2010 Aug;113(2):270-9. doi: 10.3171/2009.9.JNS09708.
6
Technical advancement in regulatory T cell isolation and characterization using CD127 expression in patients with malignant glioma treated with autologous dendritic cell vaccination.采用 CD127 表达对接受自体树突状细胞疫苗治疗的恶性胶质瘤患者调节性 T 细胞进行分离和鉴定的技术进展。
J Immunol Methods. 2010 Jan 31;352(1-2):169-73. doi: 10.1016/j.jim.2009.10.007. Epub 2009 Oct 27.
7
Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines.对荷胶质瘤小鼠体内转化生长因子-β的系统性抑制可提高胶质瘤相关抗原肽疫苗的治疗效果。
Clin Cancer Res. 2009 Nov 1;15(21):6551-9. doi: 10.1158/1078-0432.CCR-09-1067. Epub 2009 Oct 27.
8
An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme.表皮生长因子受体变异 III 靶向疫苗在多形性胶质母细胞瘤患者中安全且具有免疫原性。
Mol Cancer Ther. 2009 Oct;8(10):2773-9. doi: 10.1158/1535-7163.MCT-09-0124.
9
Predicted epitopes of malarial merozoite surface protein 1 by bioinformatics method: a clue for further vaccine development.通过生物信息学方法预测疟原虫裂殖子表面蛋白1的表位：进一步疫苗研发的线索
J Microbiol Immunol Infect. 2009 Feb;42(1):19-21.
10
Dendritic-cell- and peptide-based vaccination strategies for glioma.基于树突状细胞和肽的胶质瘤疫苗接种策略
Neurosurg Rev. 2009 Jul;32(3):265-73; discussion 273. doi: 10.1007/s10143-009-0189-1. Epub 2009 Feb 13.
Zotero 插件