用于进一步开发胶质瘤疫苗的EPHA2上T细胞表位的发现：一项免疫组学研究
T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study.
作者信息
Wiwanitkit Viroj
机构信息
Wiwanitkit House, Bangkhae, Bangkok, Thailand.
出版信息
J Pediatr Neurosci. 2011 Jan;6(1):2-3. doi: 10.4103/1817-1745.84398.
BACKGROUND
Glioma is a deadly neurological tumor. For modern management of glioma, glioma vaccinotherapy is the new concept.
MATERIALS AND METHODS
Based on present biomedical technique, the identification of T-cell epitopes via MHC mapping can help clarify the inter-relationship of tumor and immune system. This process can be performed using advanced immunoinformatics technique.
RESULTS
Here, the author performs an immunoinformatics analysis to find alternative epitopes for glioma-related antigen, EPHA2.
CONCLUSION
After complete manipulation on EPHA2 molecules, the five best epitopes were derived.
背景
神经胶质瘤是一种致命的神经肿瘤。对于神经胶质瘤的现代治疗，神经胶质瘤疫苗疗法是一个新概念。
材料与方法
基于当前的生物医学技术，通过MHC图谱鉴定T细胞表位有助于阐明肿瘤与免疫系统之间的相互关系。这一过程可使用先进的免疫信息学技术来完成。
结果
在此，作者进行了一项免疫信息学分析，以寻找神经胶质瘤相关抗原EPHA2的替代表位。
结论
对EPHA2分子进行完整操作后，得出了五个最佳表位。
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