Wiwanitkit Viroj
Wiwanitkit House, Bangkhae, Bangkok, Thailand.
J Pediatr Neurosci. 2011 Jan;6(1):2-3. doi: 10.4103/1817-1745.84398.
Glioma is a deadly neurological tumor. For modern management of glioma, glioma vaccinotherapy is the new concept.
Based on present biomedical technique, the identification of T-cell epitopes via MHC mapping can help clarify the inter-relationship of tumor and immune system. This process can be performed using advanced immunoinformatics technique.
Here, the author performs an immunoinformatics analysis to find alternative epitopes for glioma-related antigen, EPHA2.
After complete manipulation on EPHA2 molecules, the five best epitopes were derived.
神经胶质瘤是一种致命的神经肿瘤。对于神经胶质瘤的现代治疗,神经胶质瘤疫苗疗法是一个新概念。
基于当前的生物医学技术,通过MHC图谱鉴定T细胞表位有助于阐明肿瘤与免疫系统之间的相互关系。这一过程可使用先进的免疫信息学技术来完成。
在此,作者进行了一项免疫信息学分析,以寻找神经胶质瘤相关抗原EPHA2的替代表位。
对EPHA2分子进行完整操作后,得出了五个最佳表位。