Paveliu Marian Sorin, Bengea Simona, Paveliu Fraga Silvia
"Titu Maiorescu" University, Bucharest, Romania.
Maedica (Bucur). 2011 Jan;6(1):52-8.
Doctors accuse individual variability or lack of quality of generic drugs for adverse reactions or lack of efficacy. The variability of effect of generic substitution, although accepted by clinicians as possible, is little discussed or even understood by them. The situation is really serious in the case of generic substitution of drugs with narrow therapeutic index (NTI) or critical dose. In this paper we review the basic notions of variability and effectiveness of generic medication and change of attitude that would improve the use of these drugs.
医生们指责仿制药存在个体差异或质量欠佳，从而导致不良反应或疗效不佳。尽管临床医生认可仿制药替代可能存在效果差异，但对此讨论甚少，甚至理解不足。对于治疗指数窄（NTI）或剂量关键的药物进行仿制药替代时，情况尤为严峻。在本文中，我们回顾了仿制药的变异性、有效性以及观念转变等基本概念，这些转变将有助于改善此类药物的使用。
