Clinical Virology Laboratory of the Universidade Federal de São Paulo, Discipline of Infectology, Department of Medicine, Universidade Federal de São Paulo-SP, Brazil.
J Clin Virol. 2012 Jan;53(1):82-4. doi: 10.1016/j.jcv.2011.09.006. Epub 2011 Oct 5.
Human coronaviruses (HCoVs) cause upper respiratory tract and occasionally lower respiratory tract diseases. The recently described human coronavirus NL63 has not been well investigated among Brazilian patients. We reported the clinical course of an HCoV-NL63 infection in a hospitalised patient suspected of H1N1 2009 infection during the second pandemic wave of influenza activity. A 46-year-old female, health care worker with diabetes and presenting with influenza-like illness (ILI) was admitted to the hospital. During 9 days of influenza-like symptoms, the patient had diabetes decompensation, haemorrhagic pneumonia, rhabdomyolysis, respiratory and renal failure, pericarditis, and brain edema and died. HCoV-NL63 may be a causative agent of previously unexplained respiratory illnesses.
人冠状病毒（HCoVs）可引起上呼吸道疾病，偶尔也会引起下呼吸道疾病。最近描述的人冠状病毒 NL63 在巴西患者中尚未得到很好的研究。我们报告了一例在流感活动第二次大流行期间，疑似感染 H1N1 2009 的住院患者中 HCoV-NL63 感染的临床过程。一名 46 岁的女性，糖尿病患者，表现为流感样疾病（ILI），被收治入院。在 9 天的流感样症状期间，患者出现糖尿病失代偿、出血性肺炎、横纹肌溶解、呼吸和肾功能衰竭、心包炎和脑水肿，并死亡。HCoV-NL63 可能是先前不明原因呼吸道疾病的致病因子。
