Laboratório de Virologia Clínica, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
Mem Inst Oswaldo Cruz. 2012 Aug;107(5):693-4. doi: 10.1590/s0074-02762012000500020.
The incidence and clinical features of human coronaviruses (HCoVs) among Brazilian patients with respiratory illness are not well known. We investigated the prevalence of HCoVs among Brazilian outpatients and hospitalised patients with respiratory illnesses during 2009 and 2010. To identify the HCoVs, pancoronavirus and species-specific reverse-transcriptase polymerase chain reaction assays were performed. Five of 394 samples were positive for HCoVs (1.2%): 1/182 (0.5%) outpatients and 4/212 (1.8%) hospitalised patients. The OC43 and NL63 HCoVs were identified. Two patients were admitted to the intensive care unit. Underlying chronic disease was reported in cases and one diabetic adult died. HCoVs can cause lower respiratory infections and hospitalisation. Patients with pre-existing conditions and respiratory infections should be evaluated for HCoV infections.
在巴西患有呼吸道疾病的患者中，人类冠状病毒（HCoV）的发病率和临床特征尚不清楚。我们调查了 2009 年和 2010 年期间巴西门诊和住院呼吸道疾病患者中 HCoV 的流行情况。为了鉴定 HCoV，我们进行了泛冠状病毒和种特异性逆转录酶聚合酶链反应检测。394 个样本中有 5 个 HCoV 阳性（1.2%）：182 个门诊患者中有 1 个（0.5%），212 个住院患者中有 4 个（1.8%）。鉴定出 OC43 和 NL63 两种 HCoV。两名患者被收入重症监护病房。病例中报告有基础慢性疾病，一名成年糖尿病患者死亡。HCoV 可引起下呼吸道感染和住院。患有基础疾病和呼吸道感染的患者应评估 HCoV 感染情况。
