Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.
Inflamm Res. 2012 Jan;61(1):43-51. doi: 10.1007/s00011-011-0387-5. Epub 2011 Oct 7.
Chronic low-grade inflammation, characterized by elevated plasma levels of C-reactive protein (CRP), has been inversely associated with dispositional optimism. Using a Mendelian randomization design, this study explores whether CRP haplotypes that determine CRP plasma levels are also associated with dispositional optimism.
In a sample of 1,084 community-dwelling subjects (aged 60-85 years) from three cohort studies (Arnhem Elderly Study, n = 426; Leiden Longevity Study, n = 355; Zutphen Elderly Study, n = 303), six CRP polymorphisms (rs2808628, rs2808630, rs1205, rs1800947, rs1417938, and rs3091244) coding for five common haplotypes were genotyped. The association of CRP haplotypes with CRP plasma levels and dispositional optimism was analyzed using multivariable linear regression models. Subanalyses were stratified by body mass index (BMI ≥25 kg/m(2)).
CRP haplotypes determined CRP plasma levels (adjusted β = 0.094, p < 0.001). In the whole group, no association was found between CRP haplotypes and dispositional optimism scores (adjusted β = -0.02, p = 0.45). In BMI strata, CRP haplotypes were associated with increasing levels of plasma CRP levels (adjusted β = 0.112; p = 0.002) and lower dispositional optimism levels (adjusted β = -0.068; p = 0.03) in the obese group only.
These results suggest that genetically increased CRP levels are involved in low dispositional optimism, but only in case of obesity.
慢性低度炎症的特征是 C 反应蛋白（CRP）的血浆水平升高，与性格乐观呈负相关。本研究采用孟德尔随机化设计，探讨决定 CRP 血浆水平的 CRP 单倍型是否也与性格乐观有关。
在来自三个队列研究（阿纳姆老年人研究，n=426；莱顿长寿研究，n=355；祖特芬老年人研究，n=303）的 1084 名社区居住的受试者（年龄 60-85 岁）中，检测了 6 个 CRP 多态性（rs2808628、rs2808630、rs1205、rs1800947、rs1417938 和 rs3091244），这些多态性编码 5 种常见的单倍型。采用多变量线性回归模型分析 CRP 单倍型与 CRP 血浆水平和性格乐观的关系。按体重指数（BMI≥25kg/m2）进行分层的亚分析。
CRP 单倍型决定 CRP 血浆水平（调整后的β=0.094，p<0.001）。在整个组中，CRP 单倍型与性格乐观评分之间没有相关性（调整后的β=-0.02，p=0.45）。在 BMI 分层中，CRP 单倍型与肥胖组中 CRP 血浆水平的升高（调整后的β=0.112；p=0.002）和性格乐观水平的降低（调整后的β=-0.068；p=0.03）相关。
这些结果表明，遗传上 CRP 水平升高与性格乐观度降低有关，但仅在肥胖的情况下。
