Sweelam Heba-Tollah M, Abd-Alla Howaida I, Abdelwahab Ahmed B, Gabr Mahmoud M, Kirsch Gilbert
Department of Naturawl Compounds Chemistry, National Research Centre, El-Tahrir Street, Dokki, 12622 Giza, Egypt.
Université de Lorraine, Laboratoire de Structure et Réactivité des Systèmes Moléculaires Complexes SRSMC (UMR 7565), Institut de Chimie, Physique et Matériaux (ICPM), 1 Boulevard Arago, 57070 METZ, France.
J Adv Res. 2017 Dec 27;10:21-30. doi: 10.1016/j.jare.2017.12.003. eCollection 2018 Mar.
The genus belongs to the Rubiaceae family, which contains approximately 40 species. Several species were reported to be used as a folk treatment by African indigenous people in treating some diseases such as malaria, tapeworms, dysentery, gonorrhea, syphilis and snake poisoning. This article covers the period from 1962 to 2017 and presents an overview of the biological activity of different species and describes their phytochemical traits. As a conclusion, the main secondary metabolites from species are quinones, highly oxygenated chromene-based structures, and iridoids. species are widely used in folk medicine but they have to be more investigated for their medicinal properties.
该属属于茜草科，约有40个物种。据报道，几种该属物种被非洲原住民用作民间疗法，用于治疗疟疾、绦虫、痢疾、淋病、梅毒和蛇咬伤等疾病。本文涵盖了1962年至2017年的时间段，概述了不同该属物种的生物活性，并描述了它们的植物化学特征。结论是，该属物种的主要次生代谢产物是醌类、高度氧化的基于色烯的结构和环烯醚萜类。该属物种在民间医学中广泛使用，但它们的药用特性还有待进一步研究。
