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移植中心之间的结果差异:两种公共报告方法的比较。

Outcome differences across transplant centers: comparison of two methods for public reporting.

机构信息

Graduate School of Business, Stanford University, Stanford, California, USA.

出版信息

Clin J Am Soc Nephrol. 2011 Dec;6(12):2838-45. doi: 10.2215/CJN.00300111. Epub 2011 Oct 6.

Abstract

BACKGROUND AND OBJECTIVES

Reporting of standardized patient and graft survival rates by the Scientific Registry of Transplant Recipients (SRTR) aims to influence transplant centers to improve their performance. The methodology currently used is based on calculating observed-to-expected (OE) ratios for every center. Its accuracy has not been evaluated. Here, we compare the accuracy of standardized rates across centers with the OE method to an alternative generalized mixed-effect (ME) method. We also examine the association between public reporting and center outcome improvement.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Accuracy was measured as the root mean square error (RMSE) of the difference between standardized rates from one time period to standardized rates from a future time period. Data from the United States Renal Data System on all kidney transplants between January 1, 1996, and September 30, 2009 were analyzed.

RESULTS

The ME method had a 0.5 to 4.5% smaller RMSE than the OE method. It also had a smaller range between the 5(th) and 95(th) percentile centers' standardized rates: 7.5% versus 10.5% for 3-year graft survival and 4.7% versus 7.9% for 3-year patient survival. The range did not change after the introduction of public reporting in 2001. In addition, 33% of all deaths and 29% of all graft failures in the 3 years after transplant could be attributed to differences across centers.

CONCLUSIONS

The ME method can improve the accuracy of public reports on center outcomes. An examination of the reasons why public reports have not reduced differences across centers is necessary.

摘要

背景与目的

科学移植受者注册处(SRTR)报告标准化患者和移植物存活率旨在影响移植中心以改善其表现。目前使用的方法是基于为每个中心计算观察到的与预期的(OE)比率。其准确性尚未得到评估。在这里,我们将比较标准化比率的准确性与 OE 方法的中心,并检查与公开报告和中心结果改善之间的关联。

设计、设置、参与者和测量:准确性被测量为从一个时间段到未来时间段的标准化比率之间的差异的均方根误差(RMSE)。对 1996 年 1 月 1 日至 2009 年 9 月 30 日期间美国肾脏数据系统中所有肾脏移植的数据进行了分析。

结果

ME 方法的 RMSE 比 OE 方法小 0.5%至 4.5%。它还具有较小的第 5 个和第 95 个百分位中心标准化率之间的范围:3 年移植物存活率为 7.5%比 10.5%,3 年患者存活率为 4.7%比 7.9%。2001 年引入公开报告后,范围没有改变。此外,移植后 3 年内所有死亡和所有移植物失败的 33%和 29%可以归因于中心之间的差异。

结论

ME 方法可以提高中心结果的公开报告的准确性。有必要检查为什么公开报告未能减少中心之间的差异的原因。

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