Begleiter H, Porjesz B
Department of Psychiatry, State University of New York, Health Science Center, Brooklyn 11203.
Alcohol Alcohol. 1990;25(2-3):251-6. doi: 10.1093/oxfordjournals.alcalc.a044998.
The literature dealing with electrophysiologic research in alcoholics and individuals at risk for alcoholism is reviewed. Event-related potential (ERP) differences between family history positive (FHP) and family history negative (FHN) males have been reported both prior to the ingestion of alcohol and following alcohol challenge doses. At present, the most robust of these electrophysiological findings is the lower P3 amplitude of the ERP, which has now been replicated in several laboratories. This perhaps provides a phenotypic marker, distinguishing those at risk for alcoholism.
本文综述了有关酗酒者及酗酒高危个体电生理研究的文献。已有报道称，在饮酒前及给予酒精激发剂量后，家族史阳性（FHP）男性与家族史阴性（FHN）男性之间存在事件相关电位（ERP）差异。目前，这些电生理研究结果中最有力的是ERP的P3波幅较低，这一结果现已在多个实验室得到重复验证。这或许提供了一种表型标记，用以区分酗酒高危个体。
