Schuckit M A, Gold E O, Croot K, Finn P, Polich J
Alcohol Research Center, Veterans Administration Medical Center, San Diego, CA 92161.
Biol Psychiatry. 1988 Jul;24(3):310-5. doi: 10.1016/0006-3223(88)90199-0.
The magnitude and persistence of ethanol-induced increases in the latency of the P3 event-related potential from auditory stimuli were evaluated in 21 sons of alcoholic fathers (FHP) and 21 control sons of nonalcoholics (FHN) matched on demography and drinking history. The men were assessed at baseline, 70 min after imbibing a beverage, and 240 min after drinking, with observations carried out for each individual in 3 dosage conditions (placebo, 0.75 ml/kg of ethanol, and 1.1 ml/kg of ethanol). There were no family group differences for baseline (prechallenge) P3 latencies, nor any significant group differences after placebo or low-dose ethanol challenges. However, in the high alcohol dose challenge condition, P3 latencies for FHP subjects returned toward baseline measures more quickly than for FHN men. These results are consistent with previous reports of behavioral and biochemical measures in which FHP subjects demonstrated less intense reactions or returned toward baseline conditions more rapidly after ethanol ingestion relative to the FHN controls.
在21名有酗酒父亲的儿子（FHP）和21名在人口统计学和饮酒史方面相匹配的非酗酒者的对照儿子（FHN）中，评估了乙醇诱导的听觉刺激P3事件相关电位潜伏期增加的幅度和持续性。这些男性在基线、饮用饮料后70分钟和饮酒后240分钟接受评估，对每个个体在3种剂量条件（安慰剂、0.75 ml/kg乙醇和1.1 ml/kg乙醇）下进行观察。基线（挑战前）P3潜伏期没有家族组差异，安慰剂或低剂量乙醇挑战后也没有任何显著的组间差异。然而，在高酒精剂量挑战条件下，FHP受试者的P3潜伏期比FHN男性更快地恢复到基线水平。这些结果与先前关于行为和生化测量的报告一致，在这些报告中，相对于FHN对照组，FHP受试者在摄入乙醇后表现出不太强烈的反应或更快地恢复到基线状态。
