Pollock V E, Gabrielli W F, Mednick S A, Goodwin D W
Department of Psychiatry, University of Southern California, Los Angeles 90033.
Psychiatry Res. 1988 Oct;26(1):101-4. doi: 10.1016/0165-1781(88)90092-3.
Biological sons of male alcoholics constitute one group at high risk (HR) for the development of alcoholism, and were the subjects of this study. A low dose of alcohol (0.5 g/kg) was administered to HR and control subjects. On the basis of changes in the electroencephalographic (EEG) mean alpha frequency that occurred following alcohol administration, two HR subgroups were identified. Measures obtained after alcohol administration, comprising self-ratings and an observer's assessment, distinguished the HR subgroups and control subjects; measures of visuomotor performance did not. The findings are discussed in relation to two current etiological theories bearing on the development of alcoholism: a biopsychological perspective and an initial tolerance for alcohol effects.
男性酗酒者的亲生儿子构成了酗酒发展的高风险（HR）群体，他们是本研究的对象。向高风险组和对照组受试者给予低剂量酒精（0.5克/千克）。根据酒精给药后发生的脑电图（EEG）平均阿尔法频率变化，确定了两个高风险亚组。酒精给药后获得的测量结果，包括自我评分和观察者评估，区分了高风险亚组和对照组受试者；视觉运动表现的测量结果则没有。结合目前关于酗酒发展的两种病因理论对这些发现进行了讨论：生物心理学观点和对酒精作用的初始耐受性。
