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A novel dual Dbp5/DDX19 homologue from Plasmodium falciparum requires Q motif for activity.来自恶性疟原虫的一种新型双Dbp5/DDX19同源物的活性需要Q基序。
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恶性疟原虫Dbp5/DDX19同源物解旋和ATP酶活性的抑制

Inhibition of unwinding and ATPase activities of Plasmodium falciparum Dbp5/DDX19 homolog.

作者信息

Mehta Jatin, Tuteja Renu

机构信息

Malaria Group; International Centre for Genetic Engineering and Biotechnology; Aruna Asaf Ali Marg; New Delhi, Delhi India.

出版信息

Commun Integr Biol. 2011 May;4(3):299-303. doi: 10.4161/cib.4.3.14778.

DOI:10.4161/cib.4.3.14778
PMID:21980563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3187891/
Abstract

We have recently reported the isolation and characterization of Plasmodium falciparum Dbp5/DDX19 homolog PfD66 and the results indicate that it contains ATP-dependent bipolar DNA and RNA unwinding activity, intrinsic nucleic acid-dependent ATPase and RNA-binding activities. In the present study we report the effect of a number of compounds such as actinomycin D, aphidicolin, camptothecin, cyclophosphamide, 4',6'-di-amidino-2-phenylindole (DAPI), daunorubicin, distamycin, ethidium bromide, ellipticine, genistein, mitoxantrone, nalidixic acid, netropsin, nogalamycin, novobiocin and VP-16 on the DNA unwinding and ATPase activities of PfD66. The results indicate that DAPI, ethidium bromide, netropsin and nogalamycin efficiently inhibited the helicase and ATPase activities of PfD66. These studies will make an important contribution in understanding the mechanism of DNA unwinding by Plasmodium falciparum helicase PfD66.

摘要

我们最近报道了恶性疟原虫Dbp5/DDX19同源物PfD66的分离和特性鉴定，结果表明它具有依赖ATP的双极DNA和RNA解旋活性、内在的依赖核酸的ATP酶活性和RNA结合活性。在本研究中，我们报道了放线菌素D、阿非迪霉素、喜树碱、环磷酰胺、4',6'-二脒基-2-苯基吲哚（DAPI）、柔红霉素、偏端霉素、溴化乙锭、玫瑰树碱、染料木黄酮、米托蒽醌、萘啶酸、纺锤菌素、诺加霉素、新生霉素和VP-16等多种化合物对PfD66的DNA解旋和ATP酶活性的影响。结果表明，DAPI、溴化乙锭、纺锤菌素和诺加霉素能有效抑制PfD66的解旋酶和ATP酶活性。这些研究将为理解恶性疟原虫解旋酶PfD66的DNA解旋机制做出重要贡献。