Stojsić Jelena, Vucinić-Mihailović Violeta, Jovanović Dragana, Stojković Mira, Videnović-Ivanov Jellca, Filipović Snezana
Department of Thoracopulmonary Pathology, Service of Pathology, Clinical Centre of Serbia, Belgrade, Serbia.
Srp Arh Celok Lek. 2011 Jul-Aug;139(7-8):481-5.
INTRODUCTION; Sarcoidosis is a multisystem, granulomatous disease of unknown etiology. Sarcoid granulomas appear as immunological response to a particular but still unknown agent of the human body.
The main purpose of this study was to point out the important fact that the exact diagnosis of sarcoidosis must be estimated by clinical and pathological correlation, and team cooperation between the clinician and the pathologist.
Of 751 patients referred with the suspected diagnosis of sarcoidosis, from 1995 to 1999, 663 (431 female and 232 male) were analyzed and confirmed as having sarcoidosis stage I-III based on biopsy findings obtained by bronchoscopy, open lung biopsy, skin biopsy, liver biopsy or splenectomy.
Diagnosis of sarcoidosis was made in 663 patients, 431 females and 232 males (ratio 1.9:1). The average age of patients varied from 16 to 67 years, with those below age 50 years being predominant (78.4%). The highest number of patients was diagnosed in stage I of lung sarcoidosis (81.7%). Sarcoidosis was the most common cause of hilar and mediastinal lymphadenopathy (72.2%).
Biopsy is a necessary diagnostic procedure for pathological diagnosis of sarcoid granuloma before treatment even in patients where clinical, radiological, biochemical and immunological tests imply the diagnosis of sarcoidosis.
引言；结节病是一种病因不明的多系统肉芽肿性疾病。结节病肉芽肿表现为对人体某种特定但仍未知因素的免疫反应。
本研究的主要目的是指出一个重要事实，即结节病的确切诊断必须通过临床与病理的相关性以及临床医生和病理学家之间的团队合作来评估。
在1995年至1999年期间转诊疑似结节病诊断的751例患者中，对663例（431例女性和232例男性）进行了分析，并根据支气管镜检查、开胸肺活检、皮肤活检、肝活检或脾切除术获得的活检结果确诊为I - III期结节病。
663例患者被诊断为结节病，其中女性431例，男性232例（比例为1.9:1）。患者的平均年龄在16至67岁之间，以50岁以下者为主（78.4%）。肺结节病I期诊断的患者数量最多（81.7%）。结节病是肺门和纵隔淋巴结肿大最常见的原因（72.2%）。
即使在临床、放射学、生化和免疫学检查提示结节病诊断的患者中，活检也是治疗前结节病肉芽肿病理诊断的必要诊断程序。
