Discipline of Exercise and Sport Science, Faculty of Health Sciences, The University of Sydney, Sydney, New South Wales, Australia.
Obes Rev. 2012 Feb;13(2):150-61. doi: 10.1111/j.1467-789X.2011.00938.x. Epub 2011 Oct 10.
A growing number of studies suggest a potential link between obesity and altered iron metabolism. The purpose of this systematic review was to examine existing literature on iron status in obese populations. A comprehensive literature search was conducted. Included studies recruited participants ≥ 18 years with a body mass index ≥ 30 kg m(-2) and provided descriptive statistics for haemoglobin or ferritin at a minimum. There were 25 studies meeting all eligibility criteria, of these 10 examined iron status in free-living obese individuals and 15 reported baseline iron biomarkers from bariatric surgery candidates. Non-obese comparison groups were used by 10 (40%) articles. In these, seven obese groups reported higher mean haemoglobin concentration; six reported significantly higher ferritin concentration; and four significantly lower transferrin saturation. Due to insufficient data, it was not possible to make conclusions regarding mean differences for soluble transferrin receptor (sTfR), hepcidin or C-reactive protein. Existing evidence suggests a tendency for higher haemoglobin and ferritin concentration and lower transferrin saturation in obesity. Alternation of iron biomarkers in obese populations may be a result of obesity-related inflammation and/or related comorbidities. Further research incorporating measurement of inflammatory cytokines, sTfR and hepcidin is required to confirm the impact of obesity on iron status.
越来越多的研究表明肥胖与铁代谢改变之间存在潜在联系。本系统评价的目的是检查肥胖人群中铁状况的现有文献。进行了全面的文献检索。纳入的研究招募了年龄≥ 18 岁、体重指数≥ 30 kg m(-2)的参与者，并至少提供了血红蛋白或铁蛋白的描述性统计数据。有 25 项研究符合所有纳入标准，其中 10 项研究检查了自由生活肥胖个体的铁状况，15 项研究报告了肥胖症手术候选人的基线铁生物标志物。10 篇（40%）文章使用了非肥胖对照组。在这些研究中，有 7 个肥胖组报告了更高的平均血红蛋白浓度；6 个报告了明显更高的铁蛋白浓度；4 个报告了明显更低的转铁蛋白饱和度。由于数据不足，无法就可溶性转铁蛋白受体 (sTfR)、铁调素或 C 反应蛋白的平均差异做出结论。现有证据表明，肥胖人群中的血红蛋白和铁蛋白浓度较高，转铁蛋白饱和度较低。肥胖人群中铁生物标志物的改变可能是肥胖相关炎症和/或相关合并症的结果。需要进一步研究，包括测量炎症细胞因子、sTfR 和铁调素，以确认肥胖对铁状况的影响。
