López-Mejías R, García-Bermúdez M, González-Juanatey C, Castañeda S, Miranda-Filloy J A, Gómez-Vaquero C, Fernández-Gutiérrez B, Balsa A, Pascual-Salcedo D, Blanco R, González-Álvaro I, Llorca J, Martín J, González-Gay M A
Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain.
Tissue Antigens. 2011 Dec;78(6):438-41. doi: 10.1111/j.1399-0039.2011.01774.x. Epub 2011 Oct 10.
Interleukin-6 (IL-6) is a key mediator of inflammation in rheumatoid arthritis (RA) and its actions may be controlled by the IL-6 receptor (IL-6R). IL-6 transducer (IL-6ST/ gp130) is the signal transducing subunit of the IL-6R. We assessed the influence of the IL6R and the IL6ST/gp130 genes in the risk of cardiovascular (CV) disease in RA. For this purpose, 1250 Spanish patients with RA were genotyped for the IL6R rs2228145 and IL6ST/gp130 rs2228044 functional gene polymorphisms. Patients were stratified according to the presence or absence of CV events. Also, a subgroup of patients without CV events was assessed for the presence of subclinical atherosclerosis using two surrogate markers of atherosclerosis (flow-mediated endothelium-dependent vasodilatation and carotid intima-media thickness). No significant differences in the genotype and allele frequencies for both gene polymorphisms between patients with and without CV events were observed. It was also the case when values of surrogate markers of atherosclerosis were compared according to IL6R and IL6ST genotype frequencies. In conclusion, our results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA.
白细胞介素-6（IL-6）是类风湿关节炎（RA）炎症的关键介质，其作用可能受白细胞介素-6受体（IL-6R）调控。白细胞介素-6转导蛋白（IL-6ST/gp130）是IL-6R的信号转导亚基。我们评估了IL-6R和IL-6ST/gp130基因对RA患者心血管（CV）疾病风险的影响。为此，对1250名西班牙RA患者进行了IL-6R rs2228145和IL-6ST/gp130 rs2228044功能基因多态性的基因分型。根据是否发生CV事件对患者进行分层。此外，使用两种动脉粥样硬化替代标志物（血流介导的内皮依赖性血管舒张和颈动脉内膜中层厚度）对无CV事件的患者亚组进行亚临床动脉粥样硬化评估。在有或无CV事件的患者之间，未观察到两种基因多态性的基因型和等位基因频率有显著差异。根据IL-6R和IL-6ST基因型频率比较动脉粥样硬化替代标志物的值时，情况也是如此。总之，我们的结果未证实IL-6R rs2228145和IL-6ST/gp130 rs2228044多态性与RA患者的CV疾病有关联。
