Department of Genetics, University of Cambridge, Downing Site, Cambridge CB2 3EH, UK.
Curr Opin Cell Biol. 2011 Dec;23(6):650-6. doi: 10.1016/j.ceb.2011.09.007. Epub 2011 Oct 5.
Stem and progenitor cells are populations of cells that retain the capacity to populate specific lineages and to transit this capacity through cell division. However, attempts to define markers for stem cells have met with limited success. Here we consider whether this limited success reflects an intrinsic requirement for heterogeneity with stem cell populations. We focus on Embryonic Stem (ES) cells, in vitro derived cell lines from the early embryo that are considered both pluripotent (able to generate all the lineages of the future embryo) and indefinitely self renewing. We examine the relevance of recently reported heterogeneities in ES cells and whether these heterogeneities themselves are inherent requirements of functional potency and self renewal.
干细胞和祖细胞是一类具有特定谱系分化能力并能通过细胞分裂传递这种能力的细胞群体。然而，试图定义干细胞标记物的尝试取得的成功有限。在这里，我们考虑这种有限的成功是否反映了干细胞群体内在的异质性要求。我们专注于胚胎干细胞（ES）细胞，这是从早期胚胎中体外分离出来的细胞系，被认为具有多能性（能够产生未来胚胎的所有谱系）和无限自我更新的能力。我们研究了最近报道的 ES 细胞中的异质性的相关性，以及这些异质性本身是否是功能潜力和自我更新的固有要求。
