Program in Stem Cell and Regenerative Medicine, Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA.
Program in Stem Cell and Regenerative Medicine, Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA.
Cell Signal. 2012 Feb;24(2):369-377. doi: 10.1016/j.cellsig.2011.09.023. Epub 2011 Oct 1.
R-spondins (RSPOs) are a family of cysteine-rich secreted proteins containing a single thrombospondin type I repeat (TSR) domain. A vast amount of information regarding cellular signaling and biological functions of RSPOs has emerged over the last several years, especially with respect to their roles in the activation of the WNT signaling pathway. The identification of several classes of RSPO receptors may indicate that this family of proteins can affect several signaling cascades. Herein, we summarize the current understanding of RSPO signaling and its biological functions, and discuss its potential therapeutic implications to human diseases.
RSPO（R 型分泌蛋白）是富含半胱氨酸的分泌蛋白家族，含有一个单一的血栓反应蛋白型 I 重复（TSR）结构域。在过去的几年中，大量关于 RSPO 的细胞信号和生物学功能的信息已经出现，特别是关于它们在 WNT 信号通路激活中的作用。几种 RSPO 受体的鉴定可能表明该蛋白家族可以影响几种信号级联反应。在此，我们总结了 RSPO 信号及其生物学功能的最新认识，并讨论了其对人类疾病的潜在治疗意义。
