Sanchis-Bielsa Jose Maria, Bagán Jose Vicente, Poveda Rafael, Salvador Inmaculada
Service of Stomatology, Valencia University General Hospital, Valencia University Medical and Dental School, Valencia, Spain.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Aug;108(2):237-41. doi: 10.1016/j.tripleo.2009.03.032.
Subcutaneous or submucosal infiltration of cosmetic materials is a very common practice, because of the ease with which such materials can be deposited, and their presumed innocuousness. However, in recent years there have been reports of foreign body granulomatous reactions occurring many years after infiltration.
Data were collected on the clinical manifestations, histopathological findings, treatment, and course of the lesions of 15 patients.
One male and 14 females presented orofacial swelling an average of 7 years after the infiltration of silicone (n = 9), hyaluronic acid (n = 2), collagen (n = 2), methacrylate (n = 1), and polyalkylimide (n = 1). The patients were treated mainly with systemic corticosteroids, and were followed for an average of 17 months.
Systemic corticosteroids are able to control granulomatous reactions, which manifest in the form of outbreaks and tend to undergo spontaneous remission over the years.
由于化妆品材料易于沉积且假定无害，皮下或粘膜下注射化妆品材料是一种非常常见的做法。然而，近年来有报道称，注射多年后会发生异物肉芽肿反应。
收集了15例患者病变的临床表现、组织病理学发现、治疗及病程的数据。
1例男性和14例女性在注射硅酮（n = 9）、透明质酸（n = 2）、胶原蛋白（n = 2）、甲基丙烯酸酯（n = 1）和聚烷基酰亚胺（n = 1）后平均7年出现口面部肿胀。患者主要接受全身性皮质类固醇治疗，平均随访17个月。
全身性皮质类固醇能够控制以爆发形式出现且多年来往往会自发缓解的肉芽肿反应。
