SA Pathology, Adelaide, South Australia 5000,
Rheumatology (Oxford). 2011 Dec;50(12):2166-75. doi: 10.1093/rheumatology/ker291. Epub 2011 Oct 8.
The study of primary hip OA is continuing to redefine what was once considered a stagnant pathology as one of dynamic change, occurring over a long period of time involving the many composite tissue types of the joint including the bone. Examination of the inverse relationships evident between OA and fracture cohorts, including individuals with osteoporosis (OP), indicates an imbalance in formation and resorption in the bony component of both pathologies. This review contains an overview of primary OA followed by an assessment of differential gene expression and altered cellular characteristics identified in the bony compartments of primary hip OA, with a focus on the wingless mouse mammary tumor virus integration (Wnt) and TGF-β signalling pathways. The studies reviewed here suggest that OA is a systemic disease involving the bone and validate the assessment of molecular changes to further investigate this complex disease.
原发性髋关节炎的研究不断重新定义曾经被认为是静态病理的内容，将其定义为一个长期动态变化的过程，涉及关节的多种复合组织类型，包括骨骼。对 OA 和骨折队列之间明显的反向关系的研究，包括骨质疏松症（OP）患者，表明两种病理的骨成分的形成和吸收之间存在不平衡。本综述概述了原发性 OA，然后评估了原发性髋关节炎骨腔中鉴定的差异基因表达和改变的细胞特征，重点关注无翅型鼠乳腺瘤病毒整合（Wnt）和 TGF-β信号通路。本文回顾的研究表明，OA 是一种全身性疾病，涉及骨骼，并验证了对分子变化的评估，以进一步研究这种复杂的疾病。
