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Paradigm shifting vaccines: prophylactic vaccines against latent varicella-zoster virus infection and against HPV-associated cancer.具有范式转移意义的疫苗：针对潜伏性水痘-带状疱疹病毒感染和 HPV 相关癌症的预防性疫苗。
Curr Opin Virol. 2011 Oct;1(4):268-79. doi: 10.1016/j.coviro.2011.07.007.
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HPV vaccines - A review of the first decade.HPV 疫苗——首个十年的回顾。
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Breadth and Functionality of Varicella-Zoster Virus Glycoprotein-Specific Antibodies Identified after Zostavax Vaccination in Humans.水痘带状疱疹病毒糖蛋白特异性抗体的广度和功能在人类接种 Zostavax 后得到鉴定。
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本文引用的文献

1
Prevention and treatment of papillomavirus-related cancers through immunization.通过免疫接种预防和治疗人乳头瘤病毒相关癌症。
Annu Rev Immunol. 2011;29:111-38. doi: 10.1146/annurev-immunol-031210-101308.
2
Quadrivalent human papillomavirus vaccination and trends in genital warts in Australia: analysis of national sentinel surveillance data.四价人乳头瘤病毒疫苗接种与澳大利亚生殖器疣的趋势：全国哨点监测数据分析。
Lancet Infect Dis. 2011 Jan;11(1):39-44. doi: 10.1016/S1473-3099(10)70225-5. Epub 2010 Nov 8.
3
Effect of a zoster vaccine on herpes zoster-related interference with functional status and health-related quality-of-life measures in older adults.带状疱疹疫苗对老年人带状疱疹相关功能状态和健康相关生活质量的影响。
J Am Geriatr Soc. 2010 Sep;58(9):1634-41. doi: 10.1111/j.1532-5415.2010.03021.x.
4
Zoster vaccine: current status and future prospects.带状疱疹疫苗：现状与未来前景。
Clin Infect Dis. 2010 Jul 15;51(2):197-213. doi: 10.1086/653605.
5
Current understanding of the mechanism of HPV infection.目前对 HPV 感染机制的认识。
Gynecol Oncol. 2010 Jun;118(1 Suppl):S12-7. doi: 10.1016/j.ygyno.2010.04.004.
6
A summary of the post-licensure surveillance initiatives for GARDASIL/SILGARD.佳达修/卉妍康上市后监测计划概述。
Vaccine. 2010 Jul 5;28(30):4719-30. doi: 10.1016/j.vaccine.2010.04.070. Epub 2010 May 6.
7
Rate of cervical cancer, severe intraepithelial neoplasia, and adenocarcinoma in situ in primary HPV DNA screening with cytology triage: randomised study within organised screening programme.细胞学分流的 HPV DNA 初筛在宫颈癌、重度上皮内瘤变和原位腺癌中的检出率：一项在组织化筛查项目中开展的随机研究。
BMJ. 2010 Apr 27;340:c1804. doi: 10.1136/bmj.c1804.
8
Trivalent Human Papillomavirus (HPV) VLP vaccine covering HPV type 58 can elicit high level of humoral immunity but also induce immune interference among component types.三价人乳头瘤病毒（HPV）病毒样颗粒（VLP）疫苗涵盖 HPV 58 型，可以诱导高水平的体液免疫，但也会导致各型之间的免疫干扰。
Vaccine. 2010 Apr 26;28(19):3479-87. doi: 10.1016/j.vaccine.2010.02.057. Epub 2010 Mar 6.
9
Post-licensure monitoring of HPV vaccine in the United States.美国 HPV 疫苗上市后监测。
Vaccine. 2010 Jul 5;28(30):4731-7. doi: 10.1016/j.vaccine.2010.02.019. Epub 2010 Feb 25.
10
Influence of age and nature of primary infection on varicella-zoster virus-specific cell-mediated immune responses.年龄和原发感染性质对水痘-带状疱疹病毒特异性细胞免疫应答的影响。
J Infect Dis. 2010 Apr 1;201(7):1024-30. doi: 10.1086/651199.

具有范式转移意义的疫苗：针对潜伏性水痘-带状疱疹病毒感染和 HPV 相关癌症的预防性疫苗。

Paradigm shifting vaccines: prophylactic vaccines against latent varicella-zoster virus infection and against HPV-associated cancer.

机构信息

Translational Research Institute, The University of Queensland Diamantina Institute, PO Box 6116, Buranda Queensland 4102, Australia.

出版信息

Curr Opin Virol. 2011 Oct;1(4):268-79. doi: 10.1016/j.coviro.2011.07.007.

DOI:10.1016/j.coviro.2011.07.007
PMID:21984890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3185382/
Abstract

We compare the design, mechanism of action, and clinical efficacy of two recently licensed paradigm shifting vaccines. Zostavax is the first vaccine licensed to prevent disease in patients already infected with a pathogen, and is contrasted with Gardasil and Cervarix, the first vaccines designed and licensed specifically to prevent cancers.

摘要

我们比较了两种最近获得许可的具有开创性的疫苗的设计、作用机制和临床疗效。Zostavax 是第一种获准用于预防已感染病原体的患者疾病的疫苗，与之形成对比的是 Gardasil 和 Cervarix，这两种疫苗是专门为预防癌症而设计和许可的第一种疫苗。