某些大鼠和鸡胚组织中的脯氨酰3-羟化酶和4-羟化酶活性以及大鼠中这些酶活性的年龄相关变化。
Prolyl 3-hydroxylase and 4-hydroxylase activities in certain rat and chick-embryo tissues and age-related changes in their activities in the rat.
作者信息
Tryggvason K, Majamaa K, Kivirikko K I
出版信息
Biochem J. 1979 Jan 15;178(1):127-31. doi: 10.1042/bj1780127.
Abstract
Prolyl 3-hydroxylase activity, expressed per unit of extract protein, was much higher in rat kidney cortex than in the lung, liver or skin. A marked decrease in activity was found in the kidney cortex, liver and skin beyond 10 days of age. The ratio of prolyl 3-hydroxylase to 4-hydroxylase activity in the kidney cortex was 13--17 times that in the skin, that in the liver 6--8 times, and that in the lung about twice the value for the skin, there being no changes in this ratio with age. In 16-day chick embryos the highest ratios of prolyl 3-hydroxylase to 4-hydroxylase activity were found in the liver, heart, lens, aorta and kidney, and the lowest ratios in tendon, cartilage, cartilaginous and membranous bone and skin. The results suggest that the differences in the extent of prolyl 3-hydroxylation between various collagens can in part be explained by differences in the amount of prolyl e-hydroxylase activity among different cells.
摘要
以每单位提取物蛋白表示的脯氨酰3-羟化酶活性，在大鼠肾皮质中比在肺、肝或皮肤中高得多。在10日龄以后，肾皮质、肝和皮肤中的活性显著下降。肾皮质中脯氨酰3-羟化酶与4-羟化酶活性的比值是皮肤中的13 - 17倍，是肝中的6 - 8倍，是肺中的约为皮肤中的两倍，该比值不随年龄变化。在16日龄鸡胚中，脯氨酰3-羟化酶与4-羟化酶活性的最高比值见于肝、心脏、晶状体、主动脉和肾，而最低比值见于肌腱、软骨、软骨性和膜性骨以及皮肤。结果提示，不同胶原蛋白之间脯氨酰3-羟化程度的差异部分可由不同细胞中脯氨酰3-羟化酶活性量的差异来解释。
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