• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

靶向热休克反应通路治疗胰腺癌。

Targeting heat shock response pathways to treat pancreatic cancer.

机构信息

Centre Interdisciplinaire de Nanoscience de Marseille, Département de Chimie, CNRS UPR 3118, 163 Avenue de Luminy, 13288 Marseille, France.

出版信息

Drug Discov Today. 2012 Jan;17(1-2):35-43. doi: 10.1016/j.drudis.2011.09.016. Epub 2011 Oct 1.

DOI:10.1016/j.drudis.2011.09.016
PMID:21986108
Abstract

Pancreatic cancer belongs to the group of extremely aggressive human cancers; conventional cancer treatments have little impact. Increasing understanding of the pathways associated with pancreatic cancer progression has enabled the development of targeted therapy on this cancer. Heat shock proteins (HSPs) and related heat shock response (HSR) pathways control multiple important oncogenic pathways for pancreatic cancer development. Consequently, they represent promising novel targets for pancreatic cancer therapy. Various strategies have been proposed and elaborated to target HSPs/HSR in pancreatic cancer with the corresponding modulators, the details of which are highlighted in this review.

摘要

胰腺癌属于极具侵袭性的人类癌症之一；常规癌症治疗对此收效甚微。对与胰腺癌进展相关的途径的深入了解，使针对这种癌症的靶向治疗成为可能。热休克蛋白 (HSPs) 和相关的热休克反应 (HSR) 途径控制着多种与胰腺癌发展相关的重要致癌途径。因此，它们是胰腺癌治疗的有前途的新靶点。已经提出并详细阐述了各种策略来靶向胰腺癌中的 HSPs/HSR 及其相应的调节剂，本文重点介绍了这些策略的细节。

相似文献

1
Targeting heat shock response pathways to treat pancreatic cancer.靶向热休克反应通路治疗胰腺癌。
Drug Discov Today. 2012 Jan;17(1-2):35-43. doi: 10.1016/j.drudis.2011.09.016. Epub 2011 Oct 1.
2
Emerging drugs in the treatment of pancreatic cancer.胰腺癌治疗中的新兴药物。
Expert Opin Emerg Drugs. 2009 Jun;14(2):311-28. doi: 10.1517/14728210902972502.
3
Core signaling pathways and new therapeutic targets in pancreatic cancer.胰腺癌的核心信号通路和新的治疗靶点。
Chin Med J (Engl). 2010 May 5;123(9):1210-5.
4
Molecular targeting therapy for pancreatic cancer.胰腺癌的分子靶向治疗
Cancer Chemother Pharmacol. 2004 Sep;54 Suppl 1:S69-77. doi: 10.1007/s00280-004-0890-2.
5
Targeting heat shock factor 1 with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer.用三唑核苷类似物靶向热休克因子 1 以引发耐药性胰腺癌的强大抗癌活性。
Cancer Lett. 2012 May 28;318(2):145-53. doi: 10.1016/j.canlet.2011.09.043. Epub 2012 Jan 20.
6
Targeting notch to eradicate pancreatic cancer stem cells for cancer therapy.针对 Notch 以根除胰腺癌干细胞用于癌症治疗。
Anticancer Res. 2011 Apr;31(4):1105-13.
7
Targeting the heat shock response in cancer: tipping the balance in transformed cells.
Surg Oncol Clin N Am. 2013 Oct;22(4):665-84. doi: 10.1016/j.soc.2013.06.004. Epub 2013 Aug 1.
8
Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).PP1和GL-2003（抗PAK1药物，酪氨酸激酶抑制剂）联合对人胰腺癌及NF1缺陷型乳腺癌小鼠异种移植瘤的信号治疗
Cancer Lett. 2007 Jan 8;245(1-2):242-51. doi: 10.1016/j.canlet.2006.01.018. Epub 2006 Mar 15.
9
A review of systemic therapy for advanced pancreatic cancer.晚期胰腺癌全身治疗综述
Clin Adv Hematol Oncol. 2003 Jul;1(7):430-4.
10
Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway.羽扇豆醇是一种基于水果和蔬菜的三萜类化合物，它通过抑制Ras信号通路诱导人胰腺腺癌细胞凋亡。
Carcinogenesis. 2005 Nov;26(11):1956-64. doi: 10.1093/carcin/bgi157. Epub 2005 Jun 15.

引用本文的文献

1
Mechanisms of cancer cell death induction by triptolide: A comprehensive overview.雷公藤甲素诱导癌细胞死亡的机制：全面综述。
Heliyon. 2024 Jan 10;10(2):e24335. doi: 10.1016/j.heliyon.2024.e24335. eCollection 2024 Jan 30.
2
Heat Shock Proteins: Central Players in Oncological and Immuno-Oncological Tracks.热休克蛋白：肿瘤学和免疫肿瘤学途径中的核心参与者。
Adv Exp Med Biol. 2023;1409:193-203. doi: 10.1007/5584_2022_736.
3
Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers.
类药物小分子HSP27功能抑制剂通过诱导交联的Hsp27二聚体改变使肺癌细胞对吉非替尼或顺铂敏感。
Pharmaceutics. 2021 Apr 28;13(5):630. doi: 10.3390/pharmaceutics13050630.
4
Chaperones and Ubiquitin Ligases Balance Mutant p53 Protein Stability in Esophageal and Other Digestive Cancers.伴侣蛋白和泛素连接酶平衡食管和其他消化系统癌症中突变型 p53 蛋白的稳定性。
Cell Mol Gastroenterol Hepatol. 2021;11(2):449-464. doi: 10.1016/j.jcmgh.2020.10.012. Epub 2020 Oct 31.
5
AlphaB-crystallin and breast cancer: role and possible therapeutic strategies.αB-晶状体蛋白与乳腺癌：作用及可能的治疗策略。
Cell Stress Chaperones. 2021 Jan;26(1):19-28. doi: 10.1007/s12192-020-01175-0. Epub 2020 Oct 28.
6
Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures.热休克蛋白 90 抑制剂与抗癌药物在胰腺癌细胞培养物中的协同作用。
Sci Rep. 2019 Nov 7;9(1):16177. doi: 10.1038/s41598-019-52652-1.
7
A comparison of cell survival and heat shock protein expression after radiation in normal dermal fibroblasts, microvascular endothelial cells, and different head and neck squamous carcinoma cell lines.正常皮肤成纤维细胞、微血管内皮细胞和不同头颈部鳞状癌细胞系辐射后细胞存活和热休克蛋白表达的比较。
Clin Oral Investig. 2018 Jul;22(6):2251-2262. doi: 10.1007/s00784-017-2323-8. Epub 2018 Jan 6.
8
Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach.靶向热休克蛋白治疗癌症：一种有前途的治疗方法。
Int J Mol Sci. 2017 Sep 15;18(9):1978. doi: 10.3390/ijms18091978.
9
New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells.新型热休克蛋白27（HSP27）抑制剂能有效抑制癌细胞耐药性的产生。
Oncotarget. 2016 Oct 18;7(42):68156-68169. doi: 10.18632/oncotarget.11905.
10
Small Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery.破坏热休克蛋白90伴侣机制蛋白质-蛋白质相互作用的小分子抑制剂
J Cancer Prev. 2015 Mar;20(1):5-11. doi: 10.15430/JCP.2015.20.1.5.