Biology and Biochemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo, Egypt.
Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University, Cairo, Egypt.
Adv Exp Med Biol. 2023;1409:193-203. doi: 10.1007/5584_2022_736.
Heat shock proteins (HSPs) are a group of proteins that promote protein folding, inhibit denaturation of cellular proteins, and maintain other proteins' functional activities when cells are subjected to stress and/or high temperature. HSP classification is generally based on their molecular weights into large and small HSP. The family of small HSPs includes HSPs 27, 40, 60, 70, and 90. The potential roles of HSP27 and HSP70 are quite evident in different solid malignancies, including breast, colorectal, pancreatic, and liver cancers. In this chapter, the authors focus on HSP27 and HSP70 signaling in oncology and their role in different solid malignancies as well as they shed light on the novel role of HSP70 and HSP90 in the immune-oncology field.
热休克蛋白（HSPs）是一组促进蛋白质折叠、抑制细胞蛋白质变性、维持其他蛋白质功能活性的蛋白质，当细胞受到压力和/或高温时。HSP 的分类通常基于其分子量分为大 HSP 和小 HSP。小 HSP 家族包括 HSP27、40、60、70 和 90。HSP27 和 HSP70 的潜在作用在不同的实体恶性肿瘤中非常明显，包括乳腺癌、结直肠癌、胰腺癌和肝癌。在本章中，作者重点介绍 HSP27 和 HSP70 在肿瘤学中的信号转导及其在不同实体恶性肿瘤中的作用，并阐明 HSP70 和 HSP90 在肿瘤免疫领域的新作用。
