Zhang S, Wang F, Lu Z D, Li Y P, Zhang L, Jin Q H
Postgraduate Education College, Ningxia Medical University, Yinchuan, China.
J Int Med Res. 2011;39(4):1369-80. doi: 10.1177/147323001103900423.
In this randomized, double-blind, placebo-controlled, single-centre study, 80 patients (American Society of Anesthesiologists physical status I-III) received postoperative single-injection local infiltration analgesia (SLIA), continuous local infiltration analgesia (CLIA) or placebo (control group). Intravenous patient-controlled morphine was used as rescue analgesia. The CLIA group showed lower postoperative visual analogue scale (VAS) pain scores from 8 to 48 h at rest and from 16 to 48 h during activity compared with the SLIA group. The CLIA group also had significantly lower consumption of morphine from 24 to 48 h postoperatively versus the SLIA group. Patient satisfaction was higher, and maximum flexion of the knee on postoperative days 7 and 90 was greater, in the CLIA group compared with the SLIA group. CLIA provided prolonged superior analgesia and was associated with more favourable functional recovery and patient satisfaction compared with SLIA.
在这项随机、双盲、安慰剂对照的单中心研究中，80例患者（美国麻醉医师协会身体状况I-III级）接受了术后单次注射局部浸润镇痛（SLIA）、持续局部浸润镇痛（CLIA）或安慰剂（对照组）。静脉自控吗啡用作补救镇痛。与SLIA组相比，CLIA组在术后8至48小时静息时以及16至48小时活动时的视觉模拟量表（VAS）疼痛评分更低。与SLIA组相比，CLIA组术后24至48小时的吗啡消耗量也显著更低。与SLIA组相比，CLIA组患者满意度更高，术后第7天和第90天膝关节的最大屈曲度更大。与SLIA相比，CLIA提供了更长时间的优质镇痛，并且与更有利的功能恢复和患者满意度相关。
