Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, Via S. Pansini 5 80131 Naples, Italy.
World J Gastroenterol. 2011 Sep 7;17(33):3776-84. doi: 10.3748/wjg.v17.i33.3776.
The spleen could be considered a neglected organ. To date, it has been deemed an ancillary organ in portal hypertension or an organ localization in lymphoproliferative diseases, even though it has had significant attention in infectious diseases for some time. Now, it is thought to be central in regulating the immune system, a metabolic asset and involved in endocrine function with regard to nonalcoholic fatty liver disease. The main mechanisms involved in this complex network will be critically discussed in this article.
脾脏可以被认为是一个被忽视的器官。迄今为止，它在门静脉高压症中被认为是一个辅助器官，或者在淋巴增生性疾病中是一个器官定位，但它在一段时间以来在传染病方面受到了相当大的关注。现在，它被认为是调节免疫系统、代谢资产和参与非酒精性脂肪性肝病内分泌功能的中心。本文将对这个复杂网络中涉及的主要机制进行批判性讨论。
