University Hospital Basel, Internal Medicine, Basel, Switzerland.
Curr Med Res Opin. 2011 Dec;27(12):2301-8. doi: 10.1185/03007995.2011.630722. Epub 2011 Oct 25.
The GINA guidelines have redefined the primary goal of asthma treatment as achieving optimum control.
To document the level of asthma control in Switzerland, the correlations between the international guidelines by GINA and the ACT's rating of asthma control, current treatment in adolescent and adult Swiss asthma patients and factors associated with asthma control.
General practitioners and specialists (pulmonologists, allergologists and paediatricians) were invited to participate in the cross-sectional survey. Asthma control was assessed in 1093 asthma patients using both the ACT and the GINA classification for asthma control.
According to the GINA guidelines controlled asthma was found in 290 (27%) patients, when measured with the ACT 124 (11.5%) patients showed sufficient asthma control. Of the test results 65% were in accordance with each other, whereas in 85% of the non-matching results the ACT underestimated control according to GINA classification. An ACT cut-off score of ≤17 best identified uncontrolled asthma according to GINA guidelines. A total of 956 (87.7%) patients received controller medication and 849 (77.9%) patients received reliever medication. The following parameters were consistently identified to be significantly associated with insufficient asthma control in both GINA and ACT measurements: presence of exacerbation, use of reliever medication, switch of therapy and smoking.
For this study only the ACT version for adults was used.
Asthma control remains insufficient in the majority of patients, despite prescription of regular controller medication. This survey confirms the validated ACT to be useful and important in everyday practice as an objective measure for asthma control according to GINA guidelines in order to monitor control and adjust treatment.
GINA 指南重新定义了哮喘治疗的主要目标,即实现最佳控制。
记录瑞士哮喘控制水平,GINA 国际指南与 ACT 哮喘控制评分之间的相关性,瑞士青少年和成年哮喘患者的当前治疗方法以及与哮喘控制相关的因素。
邀请全科医生和专科医生(肺科医生、过敏科医生和儿科医生)参加横断面调查。使用 ACT 和 GINA 哮喘控制分类评估了 1093 例哮喘患者的哮喘控制情况。
根据 GINA 指南,控制良好的哮喘患者为 290 例(27%),而根据 ACT 评估,有 124 例(11.5%)患者的哮喘控制足够。测试结果中有 65%是一致的,而在不匹配的结果中,85%的 ACT 结果根据 GINA 分类低估了控制情况。ACT 截值≤17 时最佳识别根据 GINA 指南未控制的哮喘。共有 956 例(87.7%)患者接受了控制药物治疗,849 例(77.9%)患者接受了缓解药物治疗。在 GINA 和 ACT 测量中,以下参数一致被确定为哮喘控制不足的显著相关因素:哮喘加重、缓解药物的使用、治疗方案的调整和吸烟。
本研究仅使用了成人版的 ACT。
尽管常规使用控制药物,但大多数患者的哮喘控制仍然不足。这项调查证实了经过验证的 ACT 在日常实践中作为根据 GINA 指南监测控制和调整治疗的客观指标非常有用和重要。