Tosca Maria Angela, Del Barba Paolo, Licari Amelia, Ciprandi Giorgio
Pediatric Allergy Center, Istituto Giannina Gaslini, Genoa, 5-16146 Genova GE, Italy.
Pediatric Unit, Università Vita-Salute San Raffaele, Milan, 58-20132 Milano MI, Italy.
Children (Basel). 2020 May 7;7(5):43. doi: 10.3390/children7050043.
Asthma and allergic rhinitis (AR) are frequently associated. The objective of the treatment of asthma and AR should be the control of symptoms and disease progression. Therefore, the combined measurement of disease control is desirable. In this regard, a questionnaire able to together assess asthma and AR control has been validated: the CARAT (Control of Allergic Rhinitis and Asthma Test). A further pediatric version (CARATkids) has been generated. The current real-world study used different disease control measures in children and adolescents with asthma and rhinitis. A total of 138 children and adolescents were recruited at three allergy centers. CARAT, CARATkids, ACT (Asthma Control Test), cACT (children ACT), GINA (Global Initiative for Asthma) disease control classification, VAS (Visual Analog Scale) for asthma and nasal symptoms, and lung function were used in all subjects. There was a predominance of males (67.4%) and asthma was well-controlled (according to GINA classification) in about half the subjects. In children, the median CARAT and cACT values were 5 and 22 respectively. In adolescents, the median CARAT and ACT values were 23 for both tests. There were significant differences between CARAT and ACT ( = 0.035) as well as between CARATkids and cACT ( = 0.0001). However, the tests' outcomes were different as assessed in different domains. CARAT and CARATkids are disease-control measurements that give additional information to other tests, therefore, these different questionnaires to measure disease control complement each other.
哮喘与过敏性鼻炎（AR）常常同时出现。哮喘和AR的治疗目标应是控制症状和疾病进展。因此，联合测量疾病控制情况是可取的。在这方面，一种能够共同评估哮喘和AR控制情况的问卷已得到验证：即过敏性鼻炎和哮喘控制测试（CARAT）。还生成了一个儿科版本（CARATkids）。当前的真实世界研究在患有哮喘和鼻炎的儿童及青少年中使用了不同的疾病控制测量方法。在三个过敏中心共招募了138名儿童和青少年。所有受试者均使用了CARAT、CARATkids、哮喘控制测试（ACT）、儿童哮喘控制测试（cACT）、全球哮喘防治创议（GINA）疾病控制分类、哮喘和鼻部症状的视觉模拟量表（VAS）以及肺功能。男性占主导（67.4%），约一半的受试者哮喘得到良好控制（根据GINA分类）。在儿童中，CARAT和cACT的中位数分别为5和22。在青少年中，CARAT和ACT这两项测试的中位数均为23。CARAT与ACT之间（P = 0.035）以及CARATkids与cACT之间（P = 0.0001）存在显著差异。然而，在不同领域评估时，这些测试的结果有所不同。CARAT和CARATkids是疾病控制测量方法，能为其他测试提供额外信息，因此，这些用于测量疾病控制的不同问卷相互补充。
