PharmGKB summary: very important pharmacogene information for CYP1A2.
作者信息
Thorn Caroline F, Aklillu Eleni, Klein Teri E, Altman Russ B
机构信息
Department of Genetics, Stanford University Medical Center, Stanford, California 94305-5120, USA.
出版信息
Pharmacogenet Genomics. 2012 Jan;22(1):73-7. doi: 10.1097/FPC.0b013e32834c6efd.
Abstract
摘要
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2
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PLoS Genet. 2011 Apr;7(4):e1002033. doi: 10.1371/journal.pgen.1002033. Epub 2011 Apr 7.
3
Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.CYP1A1-CYP1A2 与 AHR 上的序列变异与咖啡消费有关。
Hum Mol Genet. 2011 May 15;20(10):2071-7. doi: 10.1093/hmg/ddr086. Epub 2011 Feb 28.
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Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease.咖啡、ADORA2A 和 CYP1A2：帕金森病中的咖啡因关联。
Eur J Neurol. 2011 May;18(5):756-65. doi: 10.1111/j.1468-1331.2011.03353.x. Epub 2011 Jan 31.
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CYP1A2 genetic polymorphisms are associated with treatment response to the antidepressant paroxetine.CYP1A2 基因多态性与抗抑郁药帕罗西汀的治疗反应有关。
Pharmacogenomics. 2010 Nov;11(11):1535-43. doi: 10.2217/pgs.10.128.
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CYP1A2 is more variable than previously thought: a genomic biography of the gene behind the human drug-metabolizing enzyme.CYP1A2 的变异性比之前认为的要大：人类药物代谢酶背后基因的基因组传记。
Pharmacogenet Genomics. 2010 Nov;20(11):647-64. doi: 10.1097/FPC.0b013e32833e90eb.
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Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 -163C>A polymorphism.大量饮用咖啡可诱导 CYP1A2，并与 CYP1A2-163C>A 多态性相关。
Eur J Clin Pharmacol. 2010 Jul;66(7):697-703. doi: 10.1007/s00228-010-0823-4.
8
Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations.分析八个世界人群中的人类 CYP1A1 和 CYP1A2 基因及其共享的双向启动子。
Hum Mutat. 2010 Jan;31(1):27-40. doi: 10.1002/humu.21132.
9
Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region.组成型雄烷受体通过5'-侧翼区域的一个共同调控元件转录激活人CYP1A1和CYP1A2基因。
Biochem Pharmacol. 2010 Jan 15;79(2):261-9. doi: 10.1016/j.bcp.2009.08.008. Epub 2009 Aug 12.
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