具有抗 HIV 活性的瑞香科植物芫花酚。

Phenols with anti-HIV activity from Daphne acutiloba.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.

出版信息

Planta Med. 2012 Jan;78(2):182-5. doi: 10.1055/s-0031-1280263. Epub 2011 Oct 11.

DOI:10.1055/s-0031-1280263

PMID:21989641

Abstract

The present paper describes the study of the phytochemical properties and anti-HIV activity of the phenolic isolates of the plateau medicinal plant Daphne acutiloba Rehd. (Thymelaeceae). Two new lignans named daphnenin (1) and daphnetone (2), along with 11 known ones, were isolated, and their structures were elucidated by 1D and 2DNMR spectroscopy aswell as HR‑ESI‑MS. In the anti-HIV activity study, daphnenin (1) and caffeic acid n-octadecyl ester (13) showed definite anti-HIVactivity with EC(50) values of 0.39 and 0.16 μg/mL, respectively.

摘要

本论文描述了高原药用植物瑞香狼毒（Thymelaeceae）酚类分离物的植物化学性质和抗 HIV 活性研究。从该植物中共分离得到两个新的木脂素，分别命名为 daphnenin（1）和 daphnetone（2），以及 11 个已知的化合物。通过 1D 和 2D NMR 光谱以及高分辨电喷雾电离质谱（HR-ESI-MS）确定了它们的结构。在抗 HIV 活性研究中，daphnenin（1）和咖啡酸正十八烷基酯（13）表现出明确的抗 HIV 活性，EC50 值分别为 0.39 和 0.16 μg/mL。