五味子中的二苯并环辛二烯木脂素及其抗 HIV-1 活性。

Dibenzocyclooctadiene lignans from Schisandra wilsoniana and their anti-HIV-1 activities.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.

出版信息

J Nat Prod. 2010 May 28;73(5):915-9. doi: 10.1021/np100067w.

DOI:10.1021/np100067w

PMID:20462233

Abstract

Twelve new dibenzocyclooctadiene lignans, marlignans A-L (1-12), together with 16 known compounds, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1-12 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques. Compounds 1-12 were evaluated for their anti-HIV activities, of which compounds 3, 6, 8, and 12 showed modest activities with therapeutic index values of 13.2, 15.6, 17.6, and 16.4, respectively.

摘要

从五味子属植物华中五味子的叶和茎中分离得到 12 个新的二苯并环辛二烯木脂素，即 marlignans A-L（1-12），并与 16 个已知化合物一起。通过包括 1D-和 2D-NMR 技术在内的光谱方法阐明了 1-12 的结构。评估了 1-12 化合物的抗 HIV 活性，其中化合物 3、6、8 和 12 的治疗指数值分别为 13.2、15.6、17.6 和 16.4，表现出适度的活性。