Mu Huai-Xue, Li Xue-Sen, Fan Peng, Yang Guang-Yu, Pu Jian-Xin, Sun Han-Dong, Hu Qiu-Fen, Xiao Wei-Lie
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China.
J Asian Nat Prod Res. 2011 May;13(5):393-9. doi: 10.1080/10286020.2011.565748.
Two new dibenzocyclooctadiene lignans, rubrilignans A and B (1, 2), together with 17 known ones, were isolated from the fruits of Schisandra rubriflora. The structures of 1 and 2 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also evaluated for their anti-HIV-1 activities and showed weak anti-HIV-1 activity with EC(50) values of 2.26 and 1.82 μg/ml, and therapeutic index values of 35.5 and 18.6, respectively.
从红花五味子果实中分离得到两个新的二苯并环辛二烯木脂素，rubrilignans A和B（1, 2），以及17个已知化合物。通过包括广泛的一维和二维核磁共振技术在内的光谱方法阐明了1和2的结构。还对化合物1和2的抗HIV-1活性进行了评估，它们显示出较弱的抗HIV-1活性，EC(50)值分别为2.26和1.82 μg/ml，治疗指数值分别为35.5和18.6。
