具有一氧化氮供体磺基异羟肟酸（SO2NHOH）环氧化酶-2药效基团的罗非昔布类似物：作为抗炎剂的合成、分子模拟及生物学评价 - Suppr

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超能文献

Rofecoxib analogues possessing a nitric oxide donor sulfohydroxamic acid (SO2NHOH) cyclooxygenase-2 pharmacophore: synthesis, molecular modeling, and biological evaluation as anti-inflammatory agents.

作者信息

Bhardwaj Atul, Huang Zhangjian, Kaur Jatinder, Knaus Edward E

机构信息

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.

出版信息

ChemMedChem. 2012 Jan 2;7(1):62-7. doi: 10.1002/cmdc.201100393. Epub 2011 Oct 11.

DOI:10.1002/cmdc.201100393

PMID:21990143

Abstract

摘要

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Rofecoxib analogues possessing a nitric oxide donor sulfohydroxamic acid (SO2NHOH) cyclooxygenase-2 pharmacophore: synthesis, molecular modeling, and biological evaluation as anti-inflammatory agents.具有一氧化氮供体磺基异羟肟酸（SO2NHOH）环氧化酶-2药效基团的罗非昔布类似物：作为抗炎剂的合成、分子模拟及生物学评价

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