Interventional Neuroradiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
J Neurointerv Surg. 2012 May;4(3):229-33. doi: 10.1136/neurintsurg-2011-010052. Epub 2011 Jun 2.
To test the effect of a music intervention on procedural anxiety, stress response and medication requirements in participants with a cerebral aneurysm or arteriovenous malformation (AVM) undergoing cerebral angiography.
A prospective pilot study was conducted using an experimental two group pre-test, post-test design. 48 participants were randomly assigned to a control group (standard care) or experimental group (standard care plus self-selected music via overhead stereo system). The stress response was measured by heart rate (HR) and systolic blood pressure (SBP) at baseline, and during and following the procedure. Anxiety was measured by the State Trait Anxiety Inventory for Adults (STAI) before and after the procedure, and total medications administered periprocedurally were recorded.
24 participants in each group were enrolled. R-ANCOVA revealed non-significant findings for HR (F=1.4; p=0.27; power=0.38) and SBP (F=2.1; p=0.10; power=0.57). The ANCOVA for anxiety revealed significantly lower STAI scores in the control group (F=3.8; p=0.003) compared with the experimental group. Independent t test analysis for the total doses of fentanyl and midazolam were found to be F=0.08, p=0.78 and F=0.38, p=0.54, respectively.
A music intervention on participants with a brain aneurysm or AVM undergoing cerebral angiography did not have a statistically significant impact on reducing the stress response, anxiety or medication requirements. Interestingly, participants in the control group had significantly less anxiety after their angiogram than did participants in the experimental group. This pilot study sets the stage for future research to further examine these findings.
测试音乐干预对接受脑血管造影的脑动脉瘤或动静脉畸形(AVM)患者的程序焦虑、应激反应和药物需求的影响。
采用实验性两群组预测试、后测试设计进行前瞻性试点研究。48 名参与者被随机分配到对照组(标准护理)或实验组(标准护理加通过头顶立体声系统自选音乐)。在基线时、程序期间和之后,通过心率(HR)和收缩压(SBP)测量应激反应。在程序前后使用成人状态特质焦虑量表(STAI)测量焦虑,记录程序期间给予的总药物。
每组 24 名参与者入组。R-ANCOVA 显示 HR(F=1.4;p=0.27;功率=0.38)和 SBP(F=2.1;p=0.10;功率=0.57)无显著差异。对照组的 STAI 评分明显低于实验组(F=3.8;p=0.003)。对芬太尼和咪达唑仑总剂量的独立 t 检验分析发现,F=0.08,p=0.78 和 F=0.38,p=0.54。
对接受脑血管造影的脑动脉瘤或 AVM 患者进行音乐干预并没有在统计学上显著降低应激反应、焦虑或药物需求。有趣的是,与实验组相比,对照组患者在血管造影后焦虑明显减轻。这项试点研究为进一步研究这些发现奠定了基础。