New antibody weapons against an old foe.

Antibodies have been used in a diagnostic capacity for many diseases and for identifying serotypes within single species of pathogens, notably between the multiple capsular polysaccharide serotypes of Streptococcus pneumoniae. For many years, the functions of antibodies in infection were thought to be limited to the opsonization of microorganisms followed by phagocytosis and to the fixing of complement. The thought that antibodies could have other functions has emerged only recently. The study by Yano and coworkers from the laboratory of Liise-anne Pirofski published in mBio [M. Yano, S. Gohil, J. R. Coleman, C. Manix, and L.-A. Pirofski, mBio 2(5):e00176-11, 2011] identifies one mechanism whereby nonopsonic antibodies enhance the transformation competence of two S. pneumoniae serotypes, which leads to an increase in genetic exchange and bacterial variability with a resulting population reduction through fratricide. These new and revealing antibody functions will add another chapter to the burgeoning story of the diversity and versatility of the immune response to bacteria.