Connolly Sean E, Benach Jorge L
Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York 11794-5120, USA.
Nat Rev Microbiol. 2005 May;3(5):411-20. doi: 10.1038/nrmicro1149.
Antibodies are the primary weapons of the mammalian immune system that are used against the tick-borne borreliae, the causative agents of relapsing fever and Lyme disease worldwide. Some antibody responses have 'traditional' functions, whereas others are more versatile and have novel functions and modes of action. At a time when the multiple functions of antibodies are being increasingly recognized and passive immunization is being revived as therapy for infectious and other diseases, the versatile nature of the antibody response to the borreliae fits well with this antibody renaissance.
抗体是哺乳动物免疫系统对抗蜱传疏螺旋体的主要武器，蜱传疏螺旋体是全球复发性发热和莱姆病的病原体。一些抗体反应具有“传统”功能，而另一些则更具通用性，具有新的功能和作用方式。在抗体的多种功能日益受到认可、被动免疫作为治疗传染病和其他疾病的疗法正在复兴之际，针对疏螺旋体的抗体反应的通用性与这一抗体复兴十分契合。
