长期接受白细胞源性α干扰素（IFN-α）治疗的患者体内针对上皮细胞的自身抗体。
Autoantibodies to epithelial cells in patients on long-term therapy with leucocyte-derived interferon-alpha (IFN-alpha).
作者信息
Karlsson-Parra A, Burman P, Hagberg H, Oberg K, Alm G, Klareskog L, Karlsson F A
机构信息
Department of Clinical Bacteriology, University of Uppsala, Sweden.
出版信息
Clin Exp Immunol. 1990 Jul;81(1):72-5. doi: 10.1111/j.1365-2249.1990.tb05293.x.
During routine screening for anti-nuclear antibodies, using rat liver tissue as substrate, a reactivity against bile duct epithelium was observed in sera from carcinoid tumour patients given human leucocyte-derived IFN-alpha (HuLe IFN-alpha). In a retrospective study, initiated by this observation, the development of serum antibodies to bile duct epithelium was observed in nine out of 12 patients with carcinoid tumours and in three out of 14 patients with hairy-cell leukaemia during their treatment with HuLe IFN-alpha. However, no bile duct reactivity was observed in sera from carcinoid or hairy-cell leukaemia in patients given recombinant IFN-alpha. When analysing the reactivity of positive sera against a panel of rat and human tissues, a uniform reactivity was observed against simple epithelial cells lining the gastrointestinal tract, pancreatic secretory ducts, fallopian tube, kidney tubuli, mesothelium and also against carcinoid tumour cells. The mechanisms promoting autoreactivity against this simple epithelial cell autoantigen is so far unknown. The cytoplasmic as well as the restricted staining pattern of simple epithelial cells may indicate autoreactivity against certain cytoskeletal intermediate filaments, such as cytokeratin 19, 18 and 8, known to be exclusively present in simple epithelial cells and tumours derived from them.
在以大鼠肝组织为底物进行抗核抗体的常规筛查过程中，观察到类癌患者接受人白细胞源干扰素-α（HuLe IFN-α）治疗后，其血清与胆管上皮发生反应。在基于这一观察结果开展的一项回顾性研究中，12例类癌患者中有9例，14例毛细胞白血病患者中有3例在接受HuLe IFN-α治疗期间出现了针对胆管上皮的血清抗体。然而，接受重组干扰素-α治疗的类癌或毛细胞白血病患者血清中未观察到胆管反应性。当分析阳性血清对一组大鼠和人组织的反应性时，发现其对胃肠道、胰腺分泌管、输卵管、肾小管、间皮的单层上皮细胞以及类癌细胞均呈现一致的反应性。目前尚不清楚促使机体针对这种单层上皮细胞自身抗原产生自身反应性的机制。单层上皮细胞的胞质以及局限的染色模式可能表明其针对某些细胞骨架中间丝存在自身反应性，如细胞角蛋白19、18和8，已知这些仅存在于单层上皮细胞及其衍生的肿瘤中。
Zotero 插件