Pileri D, Accardo-Palumbo A, D'Amelio L, D'Arpa N, Arnone G, Grisaffi C, Amico M, Brancato R, Lombardo C, Conte F
Plastic Surgery and Burns Therapy Operating Unit.
Ann Burns Fire Disasters. 2009 Mar 31;22(1):3-5.
Thermal injury is known to induce alterations in the immune system, but the precise mechanisms have yet to be elucidated. It has been shown that thermal injury in more than 20% of the total body surface area (TBSA) leads to disturbances in the cortisol metabolism and the equilibrium of the hypothalamic-pituitary-adrenal axis. We investigated the temporal relationship between serum cortisol levels, C-reactive protein, and immunoglobulin levels in the post-burn period. Twenty-one adult burn patients (mean age, 52 ± 17 yrs) were included in the study (TBSA, 10-80%); nine developed sepsis and five died. The nonseptic group consisted of twelve patients. Thirty healthy blood donors served as controls. Our results suggest that increased cortisol and decreased immunoglobulin levels could be related to severe sepsis and clinical outcome.
已知热损伤会引起免疫系统的改变，但其确切机制尚未阐明。研究表明，超过20%的体表面积（TBSA）受到热损伤会导致皮质醇代谢紊乱以及下丘脑-垂体-肾上腺轴的平衡失调。我们研究了烧伤后血清皮质醇水平、C反应蛋白和免疫球蛋白水平之间的时间关系。21名成年烧伤患者（平均年龄52±17岁）纳入本研究（TBSA为10%-80%）；9例发生脓毒症，5例死亡。非脓毒症组由12名患者组成。30名健康献血者作为对照。我们的结果表明，皮质醇升高和免疫球蛋白水平降低可能与严重脓毒症及临床结局有关。
