Discipline of Obstetrics and Gynaecology, Robinson Institute, The University of Adelaide, Adelaide, Australia.
PLoS One. 2011;6(10):e25947. doi: 10.1371/journal.pone.0025947. Epub 2011 Oct 4.
Polycystic ovary syndrome (PCOS) is a common female endocrine disorder of heterogeneous clinical presentation, high disease burden, and unknown aetiology. The disease and associated conditions cluster in families, suggesting that PCOS may be the reproductive consequence of underlying chronic disease susceptibility.
To determine whether parents of young women with PCOS were more likely to have a history of diabetes or cardiovascular disease in later adult life.
DESIGN, SETTING AND PARTICIPANTS: Structured interviews with 715 members of a cohort constructed by tracing female infants born at a single general hospital in Adelaide between 1973 and 1975. Participants were asked whether they had a pre-existing medical diagnosis of PCOS, and whether each parent had ever had high blood pressure, high cholesterol, diabetes, stroke, or heart disease. Maternal high blood pressure during pregnancy was taken from the medical record of the pregnancy with the study participant.
Mothers of women with PCOS were more likely than mothers of other women to have any cardiovascular disease (RR 1.78, 95% CI 1.29, 2.47), and nearly twice as likely to have high blood pressure (RR 1.95, 95% CI 1.38, 2.76). Fathers of women with PCOS were more than twice as likely to have heart disease (RR 2.36, 95% CI 1.44, 3.88) and over four times as likely to have had a stroke (RR 4.37, 95% CI 1.97, 9.70). Occurrence of cardiovascular disease in both mother and father are associated with the risk of PCOS in daughters. Further detailed study is required to elucidate the precise pathways that may be causally related to the observations.
多囊卵巢综合征（PCOS）是一种常见的女性内分泌疾病，具有异质性的临床表现、较高的疾病负担和未知的病因。该疾病及其相关病症在家族中聚集，表明 PCOS 可能是潜在慢性疾病易感性的生殖后果。
确定患有 PCOS 的年轻女性的父母在成年后更有可能患有糖尿病或心血管疾病。
设计、设置和参与者：对阿德莱德一家综合医院于 1973 年至 1975 年间出生的队列中 715 名成员进行了结构化访谈。参与者被问及他们是否患有 PCOS 的预先存在的医疗诊断，以及每位父母是否曾经患有高血压、高胆固醇、糖尿病、中风或心脏病。母亲在怀孕期间的高血压是从研究参与者的妊娠病历中获得的。
患有 PCOS 的女性的母亲比其他女性的母亲更有可能患有任何心血管疾病（RR 1.78，95%CI 1.29，2.47），并且高血压的可能性几乎高出两倍（RR 1.95，95%CI 1.38，2.76）。患有 PCOS 的女性的父亲患有心脏病的可能性是其他女性父亲的两倍多（RR 2.36，95%CI 1.44，3.88），中风的可能性高出四倍多（RR 4.37，95%CI 1.97，9.70）。母亲和父亲的心血管疾病发生与女儿患 PCOS 的风险相关。需要进一步详细研究以阐明可能与观察结果有因果关系的确切途径。
