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儿童伴有泡沫状巨噬细胞的显微镜下结肠炎的诊断与治疗

Diagnosis and therapy of microscopic colitis with presence of foamy macrophages in children.

作者信息

Józefczuk Jan, Woźniewicz Bogdan Marian

机构信息

Pediatric Ward, Hospital in Sandomierz, Schinzla 13, 27-600 Sandomierz, Poland.

出版信息

ISRN Gastroenterol. 2011;2011:756292. doi: 10.5402/2011/756292. Epub 2011 Jul 6.

DOI:10.5402/2011/756292
PMID:21991528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3168515/
Abstract

We discuss the diagnosis of and efficacy 5-amino-2-hydroxybenzoic acid (5-ASA), Saccharomyces boulardii, or magnesium in therapy of microscopic colitis with presence of foamy macrophages. A basis for diagnosis and inclusion to the analysed group was presence of characteristic foamy macrophages in histopathological examination of hematoxylin and eosin-stained specimens collected from the large intestine, reviewed under ×200 or ×320 magnification. No statistically significant improvement was found following the use of 5-amino-2-dihydroxybenzoic acid in therapy of the disease. The use of Saccharomyces boulardii was associated with statistically significant improvement in clinical, endoscopic, and histopathological condition. Use of magnesium caused a histological, statistically significant improvement but failed to have any effect on the clinical and endoscopic presentation. In the group of children in whom no therapeutic intervention was provided, a statistically significant spontaneous clinical improvement was observed, but no statistically significant changes in endoscopic and microscopic condition were found.

摘要

我们讨论了5-氨基-2-羟基苯甲酸（5-ASA）、布拉酵母菌或镁对存在泡沫状巨噬细胞的显微镜下结肠炎的诊断及疗效。诊断及纳入分析组的依据是，在对从大肠采集的苏木精-伊红染色标本进行组织病理学检查时，在×200或×320放大倍数下观察到特征性的泡沫状巨噬细胞。使用5-氨基-2-二羟基苯甲酸治疗该疾病后，未发现有统计学意义的改善。使用布拉酵母菌与临床、内镜及组织病理学状况的统计学显著改善相关。使用镁导致组织学上有统计学显著改善，但对临床和内镜表现无任何影响。在未进行治疗干预的儿童组中，观察到有统计学显著的自发临床改善，但内镜和显微镜下状况未发现有统计学显著变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/be977caa8a22/GASTROENTEROLOGY2011-756292.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/737b9045baa9/GASTROENTEROLOGY2011-756292.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/0b0f0ff93bb4/GASTROENTEROLOGY2011-756292.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/1a29700c8a90/GASTROENTEROLOGY2011-756292.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/260662c1cadd/GASTROENTEROLOGY2011-756292.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/066ed7920dd9/GASTROENTEROLOGY2011-756292.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/12a2d37c0dcb/GASTROENTEROLOGY2011-756292.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/be977caa8a22/GASTROENTEROLOGY2011-756292.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/737b9045baa9/GASTROENTEROLOGY2011-756292.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/0b0f0ff93bb4/GASTROENTEROLOGY2011-756292.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/1a29700c8a90/GASTROENTEROLOGY2011-756292.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/260662c1cadd/GASTROENTEROLOGY2011-756292.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/066ed7920dd9/GASTROENTEROLOGY2011-756292.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/12a2d37c0dcb/GASTROENTEROLOGY2011-756292.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6db4/3168515/be977caa8a22/GASTROENTEROLOGY2011-756292.007.jpg

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Diagnostic difficulties in inflammatory bowel disease pathology.炎症性肠病病理学中的诊断难题。
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