B3 肾上腺素受体基因 TRP64ARG 多态性与某些代谢紊乱之间的关联。
An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances.
机构信息
National Centre of Cardiology and Internal medicine named by M. Mirrakhimov, T.Moldo 3, Bishkek, 720040, Kyrgyzstan.
出版信息
Cardiovasc Diabetol. 2011 Oct 12;10:89. doi: 10.1186/1475-2840-10-89.
BACKGROUNDS
B3 adrenoreceptors (ADRB3) are abundant in adipose tissue and play the role in its metabolism and lipolysis. Some variants of the ADRB3 gene may predispose subjects for the development obesity and metabolic abnormalities in the setting of modern sedentary lifestyle. ADRB3 gene polymorphism association with metabolic disturbances has never been studied before in the ethnic Kyrgyz population.
AIM
To study an association between Trp64Arg polymorphism of the ADRB3 and metabolic syndrome (MS) components in an ethnic Kyrgyz group.
MATERIALS AND METHODS
213 Ethnic Kyrgyz volunteers over the age of 30 were enrolled in the study. The assessment plan for each individual comprised of general physical and anthropometric exams as well as laboratory tests (glucose, lipid panel, insulin) and genotyping by Trp64Arg polymorphism of the ADRB3. MS diagnosis was consistent with modified ATP III criteria (2005). Logistic regression analysis was performed to test the potential independent association between Arg64 allele with obesity, abdominal obesity (AO) and arterial hypertension (AH).
RESULTS
Trp64Arg polymorphism of the ADRB3 was assessed in 213 individuals (145 men, 68 women) aged 30-73 (mean age 50.7 ± 7.6). Arg64 allele frequency was 0.239; ADRB3 genotype distribution among participants was: Trp64 homozygotes 54.5%, Trp64Arg 43.2% and Arg64 homozygotes 2.3%. There was an association between Trp64Arg и Arg64Arg genotypes and higher BMI, WC and obesity frequency (p < 0.00009), AO (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03). The logistic regression analysis showed the correlation of the Arg64 allele with obesity (OR 3.159; 95% CI 1.789-5.577) and AO (OR 1.973; 95% CI 1.118-3.481). The association between Arg64 allele and AH lost its significance after adjustment for obesity.
CONCLUSION
Arg64 allele of the ADRB3 gene in the studied group has an association with MS components such as obesity, AO and decreased HDL-C level.
背景
B3 肾上腺素能受体（ADRB3）在脂肪组织中大量存在，在其代谢和脂肪分解中发挥作用。ADRB3 基因的某些变体可能使受试者易患肥胖症和现代久坐生活方式下的代谢异常。ADRB3 基因多态性与代谢紊乱的关联在吉尔吉斯民族中从未被研究过。
目的
研究吉尔吉斯民族中 ADRB3 的 Trp64Arg 多态性与代谢综合征（MS）成分之间的关联。
材料和方法
本研究纳入了 213 名年龄在 30 岁以上的吉尔吉斯族志愿者。对每位个体的评估计划包括一般体格检查和人体测量学检查以及实验室检查（血糖、血脂谱、胰岛素）和 ADRB3 的 Trp64Arg 多态性基因分型。MS 的诊断符合改良 ATP III 标准（2005 年）。进行逻辑回归分析以测试 Arg64 等位基因与肥胖、腹型肥胖（AO）和动脉高血压（AH）之间潜在的独立关联。
结果
在 213 名年龄为 30-73 岁（平均年龄 50.7 ± 7.6 岁）的个体中评估了 ADRB3 的 Trp64Arg 多态性。Arg64 等位基因频率为 0.239；参与者中 ADRB3 基因型分布为：Trp64 纯合子 54.5%、Trp64Arg 43.2%和 Arg64 纯合子 2.3%。Trp64Arg 和 Arg64Arg 基因型与较高的 BMI、WC 和肥胖频率（p < 0.00009）、AO（p < 0.01）、2 型糖尿病（DM）（p < 0.005）和较低的高密度胆固醇（HDL-C）水平（p < 0.03）相关。逻辑回归分析显示 Arg64 等位基因与肥胖（OR 3.159；95%CI 1.789-5.577）和 AO（OR 1.973；95%CI 1.118-3.481）相关。在调整肥胖后，Arg64 等位基因与 AH 的关联失去了意义。
结论
在研究组中，ADRB3 基因的 Arg64 等位基因与肥胖症、AO 和降低的 HDL-C 水平等 MS 成分相关。
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