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胎膜早破合并感染致早产孕妇羊水中激活素 A 和抑制素 A 的调节。

Modulation of amniotic fluid activin-a and inhibin-a in women with preterm premature rupture of the membranes and infection-induced preterm birth.

机构信息

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.

出版信息

Am J Reprod Immunol. 2012 Feb;67(2):122-31. doi: 10.1111/j.1600-0897.2011.01074.x. Epub 2011 Oct 13.

DOI:10.1111/j.1600-0897.2011.01074.x
PMID:21992678
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3253234/
Abstract

PROBLEM

Activins and inhibins are important modulators of inflammatory processes. We explored activation of amniotic fluid (AF) activin-A and inhibin-A system in women with intra-amniotic infection and preterm premature rupture of the membranes (PPROM).

METHOD OF STUDY

We analyzed 78 AF samples: '2nd trimester-control' (n=12), '3rd trimester-control' (n=14), preterm labor with intact membranes [positive-AF-cultures (n=13), negative-AF-cultures (n=13)], and PPROM [positive-AF-cultures (n=13), negative-AF-cultures (n=13)]. Activin-A levels were evaluated ex-vivo following incubation of amniochorion and placental villous explants with Gram-negative lipopolysaccharide (LPS) or Gram-positive (Pam3Cys) bacterial mimics. Ability of recombinant activin-A and inhibin-A to modulate inflammatory reactions in fetal membranes was explored through explants' IL-8 release.

RESULTS

Activin-A and inhibin-A were present in human AF and were gestational age-regulated. Activin-A was significantly upregulated by infection. Lower inhibin-A levels were seen in PPROM. LPS elicited release of activin-A from amniochorion, but not from villous explants. Recombinant activin-A stimulated IL-8 release from amniochorion, an effect that was not reversed by inhibin-A.

CONCLUSION

Human AF activin-A and inhibin-A are involved in biological processes linked to intra-amniotic infection/inflammation-induced preterm birth.

摘要

问题

激活素和抑制素是炎症过程的重要调节剂。我们探讨了羊水中激活素-A 和抑制素-A 系统在羊膜内感染和早产胎膜早破（PPROM）妇女中的激活情况。

方法

我们分析了 78 份羊水样本：“中期对照”（n=12）、“晚期对照”（n=14）、胎膜完整的早产临产[阳性-AF 培养物（n=13）、阴性-AF 培养物（n=13）]和 PPROM[阳性-AF 培养物（n=13）、阴性-AF 培养物（n=13）]。通过将羊膜绒毛和胎盘绒毛外植体与革兰氏阴性脂多糖（LPS）或革兰氏阳性（Pam3Cys）细菌模拟物孵育，评估激活素-A 水平。通过外植体 IL-8 释放，探讨重组激活素-A 和抑制素-A 对胎儿膜炎症反应的调节能力。

结果

激活素-A 和抑制素-A 存在于人羊水，并受胎龄调节。感染使激活素-A 显著上调。PPROM 中抑制素-A 水平较低。LPS 从羊膜绒毛中释放激活素-A，但不从绒毛外植体中释放。重组激活素-A 刺激羊膜绒毛释放 IL-8，抑制素-A 不能逆转这一作用。

结论

人羊水激活素-A 和抑制素-A 参与与羊膜内感染/炎症引起的早产相关的生物学过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93c3/3253234/9014ff12eeb2/nihms-325769-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93c3/3253234/5389edf2f834/nihms-325769-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93c3/3253234/682351a2be92/nihms-325769-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93c3/3253234/c91b390fd089/nihms-325769-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93c3/3253234/9014ff12eeb2/nihms-325769-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93c3/3253234/5389edf2f834/nihms-325769-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93c3/3253234/682351a2be92/nihms-325769-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93c3/3253234/c91b390fd089/nihms-325769-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93c3/3253234/9014ff12eeb2/nihms-325769-f0004.jpg

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