BMC Pregnancy Childbirth. 2011 Oct 12;11:71. doi: 10.1186/1471-2393-11-71.
Preterm birth is the leading cause of neonatal mortality and perinatal morbidity. The etiology of preterm is multi-factorial and still unclear. As evidence increases for a genetic contribution to PTB, so does the need to explore genomics, transcriptomics, proteomics and metabolomics in its study. This review suggests research guidelines for the conduct of high throughput systems biology investigations into preterm birth with the expectation that this will facilitate the sharing of samples and data internationally through consortia, generating the power needed to study preterm birth using integrated "-omics" technologies. The issues to be addressed include: (1) integrated "-omics" approaches, (2) phenotyping, (3) sample collection, (4) data management-integrative databases, (5) international consortia and (6) translational feasibility. This manuscript is the product of discussions initiated by the "-Omics" Working Group at the Preterm Birth International Collaborative Meeting held at the World Health Organization, Geneva, Switzerland in April 2009.
早产是新生儿死亡和围产期发病率的主要原因。早产的病因是多因素的，目前仍不清楚。随着越来越多的证据表明遗传因素与 PTB 有关，因此需要在研究中探索基因组学、转录组学、蛋白质组学和代谢组学。这篇综述提出了进行高通量系统生物学研究早产的研究指南，期望通过合作联盟在国际上促进样本和数据的共享，利用整合的“-omics”技术研究早产所需的力量。需要解决的问题包括：（1）整合的“-omics”方法；（2）表型分析；（3）样本收集；（4）数据管理-综合数据库；（5）国际合作联盟；（6）转化的可行性。本文是 2009 年 4 月在瑞士日内瓦世界卫生组织举行的早产国际合作会议上发起的“-Omics”工作组讨论的成果。
