慢性肾衰竭及肾移植后的高密度脂蛋白
High-density lipoprotein in chronic renal failure and after renal transplantation.
作者信息
Savdie E, Gibson J C, Stewart J H, Simons L A
出版信息
Br Med J. 1979 Apr 7;1(6168):928-30. doi: 10.1136/bmj.1.6168.928.
Serum high-density-lipoprotein (HDL) cholesterol and apoprotein (apo) A concentrations were significantly reduced at the time of renal transplantation in 26 patients with chronic renal failure. In a prospective evaluation the behaviour of HDL concentrations after grafting was found to depend on renal function. Graft function was sustained in 19 patients, in whom HDL-cholesterol and apo A concentrations increased to lie within normal limits by six months after the operation. Successful transplantation also restored to normal the lipid and protein content of HDL as expressed by the ratio of HDL cholesterol to apo A. When transplant function was not sustained (seven patients), however, no changes in HDL were observed up to the time of the graft loss. Such changes in HDL with successful kidney grafting augur well in a population with many risk factors for coronary heart disease.
26例慢性肾衰竭患者肾移植时血清高密度脂蛋白（HDL）胆固醇和载脂蛋白（apo）A浓度显著降低。在一项前瞻性评估中，发现移植后HDL浓度的变化取决于肾功能。19例患者移植肾功能得以维持，术后6个月时其HDL胆固醇和apo A浓度升至正常范围。成功移植还使HDL胆固醇与apo A的比值所表示的HDL脂质和蛋白质含量恢复正常。然而，当移植肾功能未能维持时（7例患者），直至移植肾失功时HDL均未发生变化。成功肾移植后HDL的这些变化对于有许多冠心病危险因素的人群来说是个好兆头。
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