皮质类固醇治疗、血脂与冠状动脉疾病
Corticosteroid treatment, serum lipids and coronary artery disease.
作者信息
Jefferys D B, Lessof M H, Mattock M B
出版信息
Postgrad Med J. 1980 Jul;56(657):491-3. doi: 10.1136/pgmj.56.657.491.
Abstract
Serum lipids and the cholesterol concentrations in the high density lipoprotein (HDL) fractions were measured in patients receiving long-term corticosteroid treatment for connective tissue disorders and asthma. Patients who were not receiving corticosteroid treatment had blood lipid levels which did not differ from those of healthy people. However, female (but not male) patients who had received prednisolone for a mean period of 3.1 years had a significant elevation in total cholesterol and a large decrease in HDL cholesterol. It seems possible that high levels of corticosteroids may increase the incidence of premenopausal ischaemic heart disease in females.
摘要
对因结缔组织疾病和哮喘接受长期皮质类固醇治疗的患者，测定了血清脂质及高密度脂蛋白（HDL）各组分中的胆固醇浓度。未接受皮质类固醇治疗的患者血脂水平与健康人无异。然而，平均接受泼尼松龙治疗3.1年的女性（而非男性）患者，总胆固醇显著升高，HDL胆固醇大幅降低。高水平的皮质类固醇可能会增加女性绝经前缺血性心脏病的发病率，这似乎是有可能的。
相似文献
1
Corticosteroid treatment, serum lipids and coronary artery disease.皮质类固醇治疗、血脂与冠状动脉疾病
Postgrad Med J. 1980 Jul;56(657):491-3. doi: 10.1136/pgmj.56.657.491.
2
3
Relationship between lipids and occlusive coronary artery disease.脂质与闭塞性冠状动脉疾病之间的关系。
Arch Intern Med. 1980 Aug;140(8):1067-9.
4
5
High density lipoprotein cholesterol and other serum lipids in New Zealand Maoris.新西兰毛利人的高密度脂蛋白胆固醇及其他血脂
N Z Med J. 1979 Aug 22;90(642):139-42.
6
Correlations of plasma high-density lipoprotein cholesterol levels with other plasma lipid and lipoprotein concentrations.血浆高密度脂蛋白胆固醇水平与其他血浆脂质及脂蛋白浓度的相关性。
Circulation. 1980 Nov;62(4 Pt 2):IV24-30.
7
Lipid measurements for coronary risk assessment: a review.用于冠状动脉风险评估的血脂测量：综述
Am J Med Technol. 1981 Jul;47(7):539-43.
8
Lack of effect of tocopherol on plasma lipids and lipoproteins in man.生育酚对人体血浆脂质和脂蛋白无影响。
Am J Clin Nutr. 1982 Aug;36(2):224-8. doi: 10.1093/ajcn/36.2.224.
9
Mathematical evaluation of methods for estimation of the concentration of the major lipid components of human serum lipoproteins.人血清脂蛋白主要脂质成分浓度估算方法的数学评估
J Lab Clin Med. 1976 Sep;88(3):491-505.
10
[Age and dynamics of the chief blood lipid indices among the adult population of Leningrad].[列宁格勒成年人群主要血脂指标的年龄及动态变化]
Kardiologiia. 1984 Apr;24(4):56-62.
引用本文的文献
1
Haematological Drugs Affecting Lipid Metabolism and Vascular Health.影响脂质代谢和血管健康的血液学药物
Biomedicines. 2022 Aug 10;10(8):1935. doi: 10.3390/biomedicines10081935.
2
Steroid induced hypertriglyceridemia in pregnant waman with immune thrombocytopenia - case report.免疫性血小板减少症孕妇的类固醇诱导性高甘油三酯血症——病例报告
Ann Med Surg (Lond). 2022 Apr 15;77:103636. doi: 10.1016/j.amsu.2022.103636. eCollection 2022 May.
3
Systemic glucocorticoid therapy: a review of its metabolic and cardiovascular adverse events.全身糖皮质激素治疗：代谢和心血管不良事件综述。
Drugs. 2014 Oct;74(15):1731-45. doi: 10.1007/s40265-014-0282-9.
4
Niacin Ameliorates Lipid Disturbances due to Glucocorticoid Administration in Rats.烟酰胺可改善糖皮质激素给药大鼠的脂质紊乱。
Iran J Basic Med Sci. 2012 Jul;15(4):997-1002.
5
Corticosteroid-induced adverse events in adults: frequency, screening and prevention.成人中皮质类固醇诱导的不良事件：发生率、筛查与预防
Drug Saf. 2007;30(10):861-81. doi: 10.2165/00002018-200730100-00005.
6
Methylprednisolone administration in primary biliary cirrhosis increases cholic acid turnover, synthesis, and deoxycholate concentration in bile.在原发性胆汁性肝硬化中给予甲基强的松龙可增加胆酸周转率、合成以及胆汁中脱氧胆酸盐浓度。
Dig Dis Sci. 1999 Dec;44(12):2478-83. doi: 10.1023/a:1026687022202.
本文引用的文献
1
Incidence of arteriosclerosis in patients with rheumatoid arthritis receiving long-term corticosteroid therapy.接受长期皮质类固醇治疗的类风湿性关节炎患者的动脉硬化发病率。
Ann Rheum Dis. 1972 May;31(3):196-200. doi: 10.1136/ard.31.3.196.
2
Hyperlipidaemia in asthmatic patients receiving long-term steroid therapy.接受长期类固醇治疗的哮喘患者中的高脂血症。
Br Med J. 1973 Apr 14;2(5858):85-6. doi: 10.1136/bmj.2.5858.85.
3
The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy. A study of 36 necropsy patients.系统性红斑狼疮患者的心脏及皮质类固醇治疗对其产生的影响。36例尸检患者的研究
Am J Med. 1975 Feb;58(2):243-64. doi: 10.1016/0002-9343(75)90575-6.
4
Association between oral contraceptives and myocardial infarction. A review.口服避孕药与心肌梗死之间的关联。综述。
JAMA. 1977 Jun 13;237(24):2619-22.
5
Plasma lipoproteins in renal transplant patients.肾移植患者的血浆脂蛋白
Br Med J. 1979 Jan 6;1(6155):21. doi: 10.1136/bmj.1.6155.21.
6
High-density lipoprotein in chronic renal failure and after renal transplantation.慢性肾衰竭及肾移植后的高密度脂蛋白
Br Med J. 1979 Apr 7;1(6168):928-30. doi: 10.1136/bmj.1.6168.928.
7
Serum high density lipoprotein in diabetic patients.糖尿病患者的血清高密度脂蛋白
Diabetologia. 1977 Aug;13(4):285-91. doi: 10.1007/BF01223267.
8
High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study.高密度脂蛋白作为冠心病的保护因素。弗明汉姆研究。
Am J Med. 1977 May;62(5):707-14. doi: 10.1016/0002-9343(77)90874-9.
9
The Tromsø heart-study. High-density lipoprotein and coronary heart-disease: a prospective case-control study.特罗姆瑟心脏研究。高密度脂蛋白与冠心病：一项前瞻性病例对照研究。
Lancet. 1977 May 7;1(8019):965-8. doi: 10.1016/s0140-6736(77)92274-7.
Zotero 插件