London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Viruses. 2010 May;2(5):1218-1235. doi: 10.3390/v2051218. Epub 2010 May 18.
Non-enveloped viruses such as members of Picornaviridae and Reoviridae are assembled in the cytoplasm and are generally released by cell lysis. However, recent evidence suggests that some non-enveloped viruses exit from infected cells without lysis, indicating that these viruses may also utilize alternate means for egress. Moreover, it appears that complex, non-enveloped viruses such as bluetongue virus (BTV) and rotavirus interact with lipids during their entry process as well as with lipid rafts during the trafficking of newly synthesized progeny viruses. This review will discuss the role of lipids in the entry, maturation and release of non-enveloped viruses, focusing mainly on BTV.
无包膜病毒，如小核糖核酸病毒科和呼肠孤病毒科的成员，在细胞质中组装，通常通过细胞裂解释放。然而，最近的证据表明，一些无包膜病毒在不裂解的情况下从受感染的细胞中逸出，这表明这些病毒也可能利用其他途径进行逸出。此外，似乎复杂的无包膜病毒，如蓝舌病病毒（BTV）和轮状病毒，在进入过程中以及在新合成的子代病毒运输过程中与脂质筏相互作用。这篇综述将讨论脂质在无包膜病毒进入、成熟和释放中的作用，主要集中在 BTV 上。
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