Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Viruses. 2011 Sep;3(9):1610-23. doi: 10.3390/v3091610. Epub 2011 Sep 5.
Pathogens of bacterial and viral origin hijack pathways operating in eukaryotic cells in many ways in order to gain access into the host, to establish themselves and to eventually produce their progeny. The detailed molecular characterization of the subversion mechanisms devised by pathogens to infect host cells is crucial to generate targets for therapeutic intervention. Here we review recent data indicating that coronaviruses probably co-opt membranous carriers derived from the endoplasmic reticulum, which contain proteins that regulate disposal of misfolded polypeptides, for their replication. In addition, we also present models describing potential mechanisms that coronaviruses could employ for this hijacking.
细菌和病毒病原体通过多种方式劫持真核细胞中的途径，以便进入宿主、建立自身并最终产生后代。详细的分子特征分析表明，病原体设计了感染宿主细胞的颠覆机制，这对于产生治疗干预的靶点至关重要。在这里，我们回顾了最近的数据，表明冠状病毒可能会利用来自内质网的膜载体，这些载体包含调节错误折叠多肽处理的蛋白质，用于其复制。此外，我们还提出了描述冠状病毒可能用于这种劫持的潜在机制的模型。
