Raoof Mustafa, Curley Steven A
Department of Surgical Oncology, Rice University, Houston, TX 77030, USA.
Int J Hepatol. 2011;2011:676957. doi: 10.4061/2011/676957. Epub 2011 May 29.
Targeted biological therapies for hepatocellular cancer have shown minimal improvements in median survival. Multiple pathways to oncogenesis leading to rapid development of resistance to such therapies is a concern. Non-invasive radiofrequency field-induced targeted hyperthermia using nanoparticles is a radical departure from conventional modalities. In this paper we underscore the need for innovative strategies for the treatment of hepatocellular cancer, describe the central paradigm of targeted hyperthermia using non-invasive electromagnetic energy, review the process of characterization and modification of nanoparticles for the task, and summarize data from cell-based and animal-based models of hepatocellular cancer treated with non-invasive RF energy. Finally, future strategies and challenges in bringing this modality from bench to clinic are discussed.
肝细胞癌的靶向生物疗法在中位生存期方面的改善甚微。导致对此类疗法迅速产生耐药性的多种肿瘤发生途径令人担忧。使用纳米颗粒的非侵入性射频场诱导靶向热疗与传统治疗方式截然不同。在本文中，我们强调了治疗肝细胞癌创新策略的必要性，描述了使用非侵入性电磁能进行靶向热疗的核心模式，回顾了用于该任务的纳米颗粒的表征和修饰过程，并总结了基于细胞和动物的肝细胞癌模型接受非侵入性射频能量治疗的数据。最后，讨论了将这种治疗方式从实验室应用到临床的未来策略和挑战。
