幼稚、效应和记忆 CD8 T 细胞的归巢：相似性和区别。
Naive, effector and memory CD8 T-cell trafficking: parallels and distinctions.
机构信息
Department of Microbiology, 3-512 Bowen Science Building, 51 Newton Rd, Iowa City, IA 52242, USA.
出版信息
Immunotherapy. 2011 Oct;3(10):1223-33. doi: 10.2217/imt.11.100.
Abstract
Trafficking of CD8 T cells, in both the steady-state and during episodes of infection or inflammation, is a highly dynamic process and involves a variety of receptor-ligand interactions. A thorough, mechanistic understanding of how this process is regulated could potentially lead to disease prevention strategies, through either enhancing (for infectious diseases or tumors) or limiting (for autoimmunity) recruitment of antigen-specific CD8 T cells to areas of tissue inflammation. As CD8 T cells transition from naive to effector to memory cells, changes in gene expression will ultimately dictate anatomical localization of these cells in vivo. In this article, we discuss recent advances in understanding how antigenic stimulation influences expression of various trafficking receptors and ligands, and how this determines the tissue localization of CD8 T cells.
摘要
CD8 T 细胞在稳态和感染或炎症期间的运输是一个高度动态的过程，涉及多种受体-配体相互作用。深入了解这一过程的调节机制可能会通过增强（用于传染病或肿瘤）或限制（用于自身免疫）抗原特异性 CD8 T 细胞向组织炎症部位的募集，从而导致疾病预防策略的产生。随着 CD8 T 细胞从幼稚细胞向效应细胞再向记忆细胞的转变，基因表达的变化最终将决定这些细胞在体内的解剖定位。在本文中，我们讨论了最近在理解抗原刺激如何影响各种运输受体和配体的表达以及这如何决定 CD8 T 细胞的组织定位方面的进展。
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