Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Crit Rev Microbiol. 2012 Feb;38(1):17-29. doi: 10.3109/1040841X.2011.615298. Epub 2011 Oct 13.
Campylobacter enteritis is the most reported zoonotic disease in many developed countries where it imposes a serious health burden. Campylobacter transmission to humans occurs primarily through the chicken vector. Chicks are regarded as a natural host for Campylobacter species and are colonized with C. jejuni in particular. But despite carrying a very high bacterial load in their gastrointestinal tract, these birds, in contrast to humans, do not develop pathological signs. It seems that in chickens C. jejuni principally harbors in the cecal mucosal crypts, where an inefficient inflammatory response fails to clear the bacterium from the gut. Recent intensive research resulted in an increased insight into the cross talk between C. jejuni and its avian host. This review discusses the chicken intestinal mucosal immune response upon C. jejuni entrance, leading to tolerance and persistent cecal colonization. It might in addition provide a solid base for further research regarding this topic aiming to fully understand the host-bacterium dynamics of C. jejuni in chicks and to develop effective control measures to clear this zoonotic pathogen from poultry lines.
空肠弯曲菌肠炎是许多发达国家报告最多的人畜共患病，它给人类健康带来了严重负担。空肠弯曲菌主要通过鸡这个载体传播给人类。雏鸡被认为是弯曲菌属的天然宿主，特别是定植有空肠弯曲菌。但尽管这些禽类的胃肠道内携带大量细菌，它们却不会像人类一样出现病理症状。空肠弯曲菌似乎主要寄居在盲肠黏膜隐窝内，在那里低效的炎症反应无法将细菌从肠道清除。最近的深入研究增加了人们对空肠弯曲菌与其禽类宿主之间相互作用的了解。这篇综述讨论了空肠弯曲菌进入鸡肠道黏膜后，导致机体产生耐受和持续盲肠定植的免疫反应。这可能为进一步研究该主题提供坚实的基础，旨在充分了解雏鸡中空肠弯曲菌的宿主-细菌动态，并制定有效的控制措施来清除这种人畜共患病病原体。
