Falodun Abiodun, Imieje Vincent, Erharuyi Osayewenre, Joy Ahomafor, Langer Peter, Jacob Melissa, Khan Shabanna, Abaldry Mohammed, Hamann Mark
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, 300001, Nigeria ; Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS 38655, USA.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, 300001, Nigeria ; Institute of Organic Chemistry, University of Rostock, 18509, Rostock, Germany.
Asian Pac J Trop Biomed. 2014 May;4(5):374-8. doi: 10.12980/APJTB.4.2014C1312.
To investigate the antileishmanial, antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.
The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses to obtain three known metabolites, microcyclic lathyrane diterpenoids (1-3). Structures were confirmed by comparison of 1D and 2D spectral data with literature.
The three compounds exhibited inhibition of antileishmanial, antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC50 of 8.2 and 8.7 µg/mL, respectively.
The research lends support to the ethnomedicinal use of the plant in combating microbial infections, leishmaniasis and malarial infections.
研究用于非洲民族医学的多裂麻风树纯代谢产物的抗利什曼原虫、抗菌和抗疟活性。
将尼日利亚民间医学中用于治疗细菌感染的多裂麻风树甲醇茎皮提取物进行柱色谱和高效液相色谱分析，以获得三种已知代谢产物，即微环山黧豆烷二萜类化合物（1 - 3）。通过将一维和二维光谱数据与文献进行比较来确认结构。
这三种化合物对受试生物体表现出抗利什曼原虫、抗疟和抗菌作用，化合物2和3对新型隐球菌有活性，IC50分别为8.2和8.7 µg/mL。
该研究支持了该植物在对抗微生物感染、利什曼病和疟疾感染方面的民族医学用途。
